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611425 occurrences (No.13 in the rank) during 5 years in the PubMed. [cache]

256) Saliva and use of eNAT buffer each increased detection of SARS-CoV-2 with the Xpert test; however, no single sample matrix identified all positive cases.

--- ABSTRACT ---

PMID:33688680 DOI:10.1101/2021.03.03.21251172

2021 medRxiv : the preprint server for health sciences

* Evaluation of sample collection and transport strategies to enhance yield, accessibility, and biosafety of COVID-19 RT-PCR testing.

- Sensitive, accessible, and biosafe sampling methods for COVID-19 reverse-transcriptase polymerase chain reaction (RT-PCR) assays are needed for frequent and widespread testing. We systematically evaluated diagnostic yield across different sample collection and transport workflows, including the incorporation of a viral inactivation buffer. We prospectively collected nasal swabs, oral swabs, and saliva, from 52 COVID-19 RT-PCR-confirmed patients, and nasopharyngeal (NP) swabs from 37 patients. Nasal and oral swabs were placed in both viral transport media (VTM) and eNAT™, a sterilizing transport buffer, prior to testing with the Xpert Xpress SARS-CoV-2 (Xpert) test. The sensitivity of each sampling strategy was compared using a composite positive standard. Overall, swab specimens collected in eNAT showed superior sensitivity compared to swabs in VTM (70% vs 57%, P=0.0022). Direct saliva 90.5%, (95% CI: 82%, 95%), followed by NP swabs in VTM and saliva in eNAT, was significantly more sensitive than nasal swabs in VTM (50%, P<0.001) or eNAT (67.8%, P=0.0012) and oral swabs in VTM (50%, P<0.0001) or eNAT (56%, P<0.0001). Saliva and use of eNAT buffer each increased detection of SARS-CoV-2 with the Xpert test; however, no single sample matrix identified all positive cases.

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(1)53 risk	(17)4 significantly	(33)2 CYP2B6	(50)2 likelihood
(2)32 the	(18)4 survival	(34)2 DNA	(51)2 mental
(3)19 in	(19)3 and	(35)2 ROS	(52)2 neutrophil
(4)11 levels	(20)3 at	(36)2 T	(53)2 odds
(5)8 by	(21)3 during	(38)2 airway	(54)2 patients'
(6)8 over	(22)3 exposure	(39)2 appetite,	(55)2 placental
(7)6 null	(23)3 focus	(40)2 approximately	(56)2 probability
(8)6 awareness	(24)3 for	(41)2 body	(57)2 rate
(9)6 expression	(25)3 from	(42)2 cell	(58)2 research
(10)6 or	(26)3 mortality	(43)2 demands	(59)2 resolution
(11)5 after	(27)3 sensitivity	(44)2 depressive	(60)2 retropalatal
(12)5 use	(28)3 severity	(45)2 detection	(61)2 substantially
(13)4 incidence	(29)3 signal	(46)2 health	(62)2 their
(14)4 prevalence	(30)3 time	(47)2 intracranial	(63)2 total
(15)4 production	(31)3 to	(48)2 intratumoral	(64)2 uptake
(16)4 serum	(32)3 vaccine	(49)2 lifespan	(65)2 virus

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--- WordNet output for increased --- =>力の増加 Overview of verb increase The verb increase has 2 senses (first 2 from tagged texts) 1. (86) increase -- (become bigger or greater in amount; "The amount of work increased") 2. (61) increase -- (make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted") Overview of adj increased The adj increased has 1 sense (first 1 from tagged texts) 1. (30) increased -- (made greater in size or amount or degree) --- WordNet end ---