ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for molecular out of >500 occurrences
333489 occurrences (No.56 in the rank) during 5 years in the PubMed. [no cache] 500 found
29) Taken together, these results indicate that (R)-TEMOSPho will be useful for dissecting the molecular mechanisms of megakaryocytic differentiation, and that this class of compounds represents potential therapeutic reagents for thrombocytopenia.
--- ABSTRACT ---
PMID:23166016 DOI:10.1002/term.1628
2015 Journal of tissue engineering and regenerative medicine
* 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34⁺ haematopoietic stem cells.
- In this study we showed that 2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient differentiation of megakaryocytes. Specifically, (R)-TEMOSPho induces cell cycle arrest, cell size increase and polyploidization from K562 and HEL cells, which are used extensively to model megakaryocytic differentiation. In addition, megakaryocyte-specific cell surface markers showed a dramatic increase in expression in response to (R)-TEMOSPho treatment. Importantly, we demonstrated that such megakaryocytic differentiation can also be induced from primary human CD34(+) haematopoietic stem cells. Activation of the PI3K-AKT pathway and, to a lesser extent, the MEK-ERK pathway appears to be required for this process, as blocking with specific inhibitors interferes with the differentiation of K562 cells. A subset of (R)-TEMOSPho-treated K562 cells undergoes spontaneous apoptosis and produces platelets that are apparently functional, as they bind to fibrinogen, express P-selectin and aggregate in response to SFLLRN and AYPGFK, the activating peptides for the PAR1 and PAR4 receptors, respectively. Taken together, these results indicate that (R)-TEMOSPho will be useful for dissecting the molecular mechanisms of megakaryocytic differentiation, and that this class of compounds represents potential therapeutic reagents for thrombocytopenia.
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[frequency of next (right) word to molecular]
(1)52 mechanisms (19)5 docking (37)3 recognition (55)2 heparin
(2)26 weight (20)5 information (38)3 serotyping (56)2 identification
(3)18 data (21)5 methods (39)3 sieve (57)2 knowledge
(4)18 mechanism (22)5 modeling (40)3 structure (58)2 mass
(5)16 dynamics (23)5 phylogenetic (41)3 techniques (59)2 mechanisms,
(6)15 and (24)5 targets (42)3 variance (60)2 or
(7)10 analysis (25)4 diagnosis (43)2 Dynamics (61)2 oxygen
(8)10 basis (26)4 interactions (44)2 approach (62)2 perspectives
(9)8 characterization (27)4 level (45)2 biological (63)2 phenotypic
(10)7 epidemiology (28)4 level, (46)2 classification (64)2 phylogenies
(11)7 genetic (29)4 responses (47)2 clock (65)2 probes
(12)7 imaging (30)4 target (48)2 dating (66)2 profiles
(13)6 biology (31)3 evolution (49)2 details (67)2 subtype
(14)6 changes (32)3 features (50)2 diffusion (68)2 therapies
(15)6 markers (33)3 levels (51)2 effects (69)2 underpinnings
(16)6 pathways (34)3 marker (52)2 events
(17)5 analyses (35)3 medicine (53)2 evidence
(18)5 characteristics (36)3 orbital (54)2 genetics

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--- WordNet output for molecular --- =>分子の Overview of adj molecular The adj molecular has 2 senses (first 1 from tagged texts) 1. (6) molecular -- (relating to or produced by or consisting of molecules; "molecular structure"; "molecular oxygen"; "molecular weight is the sum of all the atoms in a molecule") 2. molecular -- (relating to simple or elementary organization; "proceed by more and more detailed analysis to the molecular facts of perception"--G.A. Miller) --- WordNet end ---