ELIZA

return kwic search for new out of >500 occurrences
486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [no cache] 500 found

122) This review will cover the clinical data regarding these emergent therapies that include new generation of proteasome inhibitors (carfilzomib, ixazomib, oprozomib, and marizomib), immunomodulatory drugs (pomalidomide), monoclonal antibodies (elotuzumab and daratumumab), signal transduction modulator (perifosine), and histone deacetylase inhibitors (vorinostat and panobinostat).

--- ABSTRACT ---

PMID:23934133 DOI:10.1097/COC.0b013e3182a4676b

2015 American journal of clinical oncology

* Emerging therapies in multiple myeloma.

- The treatment of multiple myeloma has evolved significantly over the past 2 decades due to the use of high-dose chemotherapy and autologous stem cell transplantation, and the subsequent introduction of the immunomodulatory agents (thalidomide and lenalidomide) and the proteasome inhibitor (bortezomib). The median overall survival of multiple myeloma patients has increased significantly with patients younger than age 50 years experiencing a 10-year survival rate of around 40%. However, despite the increased effectiveness of the first-line agents, the majority of patients will eventually relapse and become drug resistant. Promising novel therapies have recently emerged and are being used to treat relapsed and refractory patients. This review will cover the clinical data regarding these emergent therapies that include new generation of proteasome inhibitors (carfilzomib, ixazomib, oprozomib, and marizomib), immunomodulatory drugs (pomalidomide), monoclonal antibodies (elotuzumab and daratumumab), signal transduction modulator (perifosine), and histone deacetylase inhibitors (vorinostat and panobinostat).

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[frequency of next (right) word to new]

(1)19 Zealand	(19)4 targets	(37)2 Zealand,	(55)2 important
(2)13 bone	(20)3 DP	(38)2 avenues	(56)2 innovations
(3)12 approach	(21)3 York,	(39)2 biomarkers	(57)2 instrument
(4)11 and	(22)3 approaches	(40)2 blood	(58)2 methodologies
(5)10 method	(23)3 concepts	(41)2 case	(59)2 methods
(6)9 insights	(24)3 information	(42)2 cases	(60)2 parameters
(7)7 York	(25)3 insight	(43)2 challenges	(61)2 policy
(8)7 therapeutic	(26)3 light	(44)2 co-processed	(62)2 public
(9)5 data	(27)3 media	(45)2 compound	(63)2 risk
(10)5 molecular	(28)3 molecules	(46)2 concept	(64)2 strategies
(11)5 species	(29)3 regulation	(47)2 diagnostic	(65)2 strategy
(12)4 World	(30)3 research	(48)2 driver	(66)2 subspecies
(13)4 class	(31)3 technique	(49)2 drug	(67)2 training
(14)4 clinical	(32)3 treatment	(50)2 endemic	(68)2 type
(15)4 discoveries	(33)2 Graves'	(51)2 evidence	(69)2 way
(16)4 generation	(34)2 HIV	(52)2 findings
(17)4 measure	(35)2 South	(53)2 genetic
(18)4 model	(36)2 York/Japan	(54)2 health

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---