ELIZA

return kwic search for new out of >500 occurrences
486851 occurrences (No.30 in the rank) during 5 years in the PubMed. [cache]

64) The use of mouse models has revolutionized the field of Down syndrome (DS), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment.

--- ABSTRACT ---

PMID:34803627 DOI:10.3389/fnbeh.2021.772734

2021 Frontiers in behavioral neuroscience

* Social Factors Influence Behavior in the Novel Object Recognition Task in a Mouse Model of Down Syndrome.

- The use of mouse models has revolutionized the field of Down syndrome (DS), increasing our knowledge about neuropathology and helping to propose new therapies for cognitive impairment. However, concerns about the reproducibility of results in mice and their translatability to humans have become a major issue, and controlling for moderators of behavior is essential. Social and environmental factors, the experience of the researcher, and the sex and strain of the animals can all have effects on behavior, and their impact on DS mouse models has not been explored. Here we analyzed the influence of a number of social and environmental factors, usually not taken into consideration, on the behavior of male and female wild-type and trisomic mice (the Ts65Dn model) in one of the most used tests for proving drug effects on memory, the novel object recognition (NOR) test. Using principal component analysis and correlation matrices, we show that the ratio of trisomic mice in the cage, the experience of the experimenter, and the timing of the test have a differential impact on male and female and on wild-type and trisomic behavior. We conclude that although the NOR test is quite robust and less susceptible to environmental influences than expected, to obtain useful results, the phenotype expression must be contrasted against the influences of social and environmental factors.

--- ABSTRACT END ---

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[frequency of next (right) word to new]

(1)14 therapeutic	(21)3 Zealand,	(42)2 Guinea	(62)2 means
(2)12 and	(22)3 agents	(43)2 ICDF	(63)2 melatonin
(3)10 &	(23)3 approaches	(44)2 Mexico	(64)2 molecular
(4)9 technologies	(24)3 attention	(45)2 York	(65)2 opportunities
(5)8 method	(25)3 bone	(46)2 analytical	(66)2 pandemic
(6)7 insights	(26)3 cases	(47)2 avenue	(67)2 photoreceptors
(7)7 therapies	(27)3 challenges	(48)2 classifier	(68)2 population
(8)6 Zealand	(28)3 coronary	(49)2 computational	(69)2 preventive
(9)6 approach	(29)3 drug	(50)2 concept	(70)2 questionnaire
(10)6 diagnostic	(30)3 generation	(51)2 dimension	(71)2 severe
(11)6 treatment	(31)3 information	(52)2 direction	(72)2 strategies,
(12)5 class	(32)3 insight	(53)2 discoveries	(73)2 target
(13)5 data	(33)3 model	(54)2 drugs	(74)2 targets
(14)4 ADHD	(34)3 non-invasive	(55)2 drugs,	(75)2 theoretical
(15)4 avenues	(35)3 research	(56)2 era	(76)2 tool
(16)4 chemical	(36)3 strategies	(57)2 evidence	(77)2 type
(17)4 light	(37)3 tests	(58)2 findings	(78)2 viruses
(18)4 methods	(38)3 types	(59)2 forms
(19)4 treatments	(40)2 AF	(60)2 knowledge
(20)3 England	(41)2 COVID-19	(61)2 materials,

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--- WordNet output for new --- =>新発見の, 新しい, 現代的な, 新参の Overview of adj new The adj new has 11 senses (first 5 from tagged texts) 1. (310) new -- (not of long duration; having just (or relatively recently) come into being or been made or acquired or discovered; "a new law"; "new cars"; "a new comet"; "a new friend"; "a new year"; "the New World") 2. (36) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 3. (11) raw, new -- (lacking training or experience; "the new men were eager to fight"; "raw recruits") 4. (5) new, unexampled -- (having no previous example or precedent or parallel; "a time of unexampled prosperity") 5. (3) new -- (other than the former one(s); different; "they now have a new leaders"; "my new car is four years old but has only 15,000 miles on it"; "ready to take a new direction") 6. new -- (unaffected by use or exposure; "it looks like new") 7. newfangled, new -- ((of a new kind or fashion) gratuitously new; "newfangled ideas"; "she buys all these new-fangled machines and never uses them") 8. New -- (in use after medieval times; "New Eqyptian was the language of the 18th to 21st dynasties") 9. Modern, New -- (used of a living language; being the current stage in its development; "Modern English"; "New Hebrew is Israeli Hebrew") 10. new, young -- ((of crops) harvested at an early stage of development; before complete maturity; "new potatoes"; "young corn") 11. new -- (unfamiliar; "new experiences"; "experiences new to him"; "errors of someone new to the job") Overview of adv new The adv new has 1 sense (first 1 from tagged texts) 1. (1) newly, freshly, fresh, new -- (very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes") --- WordNet end ---