* High-dose glucocorticoid therapy in the management of seizures in neonatal incontinentia pigmenti: a case report.
- Incontinentia pigmenti is an X-linked dominant disorder resulting from a mutation of IKBKG. This disorder has a classic dermatologic presentation, but neurologic involvement, with seizures and cortical infarction, can arise shortly after birth. There are no specific therapies available for the manifestations of incontinentia pigmenti. Here, we describe the clinical, electrographic, and neuroradiologic effect of systemic glucocorticoid therapy in a neonate with incontinentia pigmenti manifesting an epileptic encephalopathy. Treatment with dexamethasone led to a dramatic reduction in seizure activity and improvement in bullous lesions. A novel mutation in IKBKG is also reported.
=>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説
Overview of noun novel
The noun novel has 2 senses (first 1 from tagged texts)
1. (17) novel -- (an extended fictional work in prose; usually in the form of a story)
2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were
filled with nothing but novels"; "he burned all the novels")
Overview of adj novel
The adj novel has 2 senses (first 1 from tagged texts)
1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a
completely novel proof of a well-known theorem")
2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort")
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