ELIZA

return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found

12) Our data suggest that AN-DISE may be a novel therapeutic strategy for PCa.

--- ABSTRACT ---

PMID:33850637 DOI:10.1016/j.omtn.2021.03.002

2021 Molecular therapy. Nucleic acids

* Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells.

- Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen receptor-coregulatory genes, leading to potent androgen signaling inhibition and PCa cell death. Expression of different short hairpin/small interfering RNAs (sh-/siRNAs) designed to target TMEFF2 preferentially reduce viability of PCa but not benign cells, and growth of murine xenografts. Surprisingly, this effect is independent of TMEFF2 expression. Transcriptomic and sh/siRNA seed sequence studies indicate that expression of these toxic shRNAs lead to downregulation of androgen receptor-coregulatory and essential genes through mRNA 3' UTR sequence complementarity to the seed sequence of the toxic shRNAs. These findings reveal a form of the "death induced by survival gene elimination" mechanism in PCa cells that mainly targets AR signaling, and that we have termed androgen network death induced by survival gene elimination (AN-DISE). Our data suggest that AN-DISE may be a novel therapeutic strategy for PCa.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to novel]

(1)23 therapeutic	(18)4 strategy	(35)2 antifungal	(52)2 nonsteroidal
(2)14 approach	(19)4 therapeutics	(36)2 biomarker	(53)2 object
(3)11 and	(20)3 STAT3	(37)2 biomarkers	(54)2 opportunities
(4)10 coronavirus	(21)3 avenues	(38)2 blood	(55)2 perspectives
(5)8 insights	(22)3 bicistronic	(39)2 cardiac	(56)2 pharmaceutical
(6)8 mechanism	(23)3 compound	(40)2 cell-based	(57)2 preclinical
(7)7 method	(24)3 diagnostic	(41)2 class	(58)2 protein
(8)6 chemical	(25)3 drugs	(42)2 dietary	(59)2 proteins
(9)6 role	(26)3 genetic	(43)2 evidence-based	(60)2 reactive
(10)6 therapies	(27)3 immunotherapeutic	(44)2 human	(61)2 risk
(11)6 treatment	(28)3 methodologies	(45)2 imaging	(62)2 small-molecule
(12)5 approaches	(29)3 mouse	(46)2 infectious	(63)2 target
(13)5 drug	(30)3 small	(47)2 insight	(64)2 targets
(14)4 data	(31)2 Coronavirus	(48)2 interventions	(65)2 trial
(15)4 findings	(32)2 agents	(49)2 methodology
(16)4 in	(33)2 analgesic	(50)2 neuroprotective
(17)4 strategies	(34)2 analytical	(51)2 noninvasive

add keyword

--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---