ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for novel out of >500 occurrences
330250 occurrences (No.59 in the rank) during 5 years in the PubMed. [no cache] 500 found
3) Further research on the exact roles of these cytokines will aid the understanding of the pathogenesis and the identification of novel therapeutic approaches of OLP.
--- ABSTRACT ---
PMID:24329772 DOI:10.1111/jop.12142
2015 Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
* Inflammation-related cytokines in oral lichen planus: an overview.
- Cytokines are powerful mediators which play a central role in both innate and adapted immune responses. Aberrant productions of cytokines may lead to the onset of immune deficiency, allergy or autoimmunity, which are involved in the mechanisms of various immune-mediated inflammatory diseases. Oral lichen planus (OLP) is a chronic inflammation disease affecting the oral mucosa with unknown aetiology. Previous studies have described the abnormal expression patterns of various inflammation-related cytokines, such as IL-1, 2, 4, 5, 6, 8, 10, 12, 17, 18, TGF-β, IFN-γ and TNF-α, in lesions, saliva, serum and peripheral blood mononuclear cells from patients with OLP, which may reflect the immune dysregulation status and emerge as central players in the immunopathogenesis of OLP. Besides, the gene polymorphisms of several cytokines such as IFN-γ, TNF-α, IL-4, IL-10 have been found to be involved in the susceptibility of OLP. In this review, we gave a brief introduction of the characteristics and biological functions of these inflammation-related cytokines and summarized for the first time the current knowledge on the involvement of inflammation-related cytokines in OLP. Further research on the exact roles of these cytokines will aid the understanding of the pathogenesis and the identification of novel therapeutic approaches of OLP.
--- ABSTRACT END ---
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(1)22 therapeutic (17)3 mutation (33)2 approaches (49)2 information
(2)11 and (18)3 paradigm (34)2 autosomal (50)2 inhibitors
(3)8 mechanism (19)3 role (35)2 candidate (51)2 learning
(4)8 method (20)3 strain (36)2 cardiac (52)2 modulators
(5)7 approach (21)3 target (37)2 clinical (53)2 object
(6)7 mutations (22)3 targeted (38)2 compounds (54)2 oral
(7)6 therapies (23)3 targets (39)2 data (55)2 polymer
(8)5 technique (24)3 treatment (40)2 described (56)2 potent
(9)4 strategies (25)3 type (41)2 dual (57)2 prognostic
(10)4 strategy (26)3 words (42)2 electroporation (58)2 putative
(11)4 surgical (27)2 *null* (43)2 finding (59)2 recombinants
(12)3 antibacterial (28)2 anti-tumor (44)2 findings (60)2 results
(13)3 drug (29)2 antibiotic (45)2 form (61)2 therapeutical
(14)3 homozygous (30)2 anticancer (46)2 genetic (62)2 titanium
(15)3 insights (31)2 application (47)2 imaging (63)2 treatments
(16)3 mechanisms (32)2 applications (48)2 in

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--- WordNet output for novel --- =>1.よく知られていない, 新しい, 珍奇な, 異常な, 新奇な, 目新しい, 2.(長編)小説 Overview of noun novel The noun novel has 2 senses (first 1 from tagged texts) 1. (17) novel -- (an extended fictional work in prose; usually in the form of a story) 2. novel -- (a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels") Overview of adj novel The adj novel has 2 senses (first 1 from tagged texts) 1. (6) fresh, new, novel -- (original and of a kind not seen before; "the computer produced a completely novel proof of a well-known theorem") 2. novel, refreshing -- (pleasantly new or different; "common sense of a most refreshing sort") --- WordNet end ---