kwic
observed
observed
right
off
ON
261
1
100
500
strict
ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for observed out of >500 occurrences
392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to observed]
392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [cache]
| 261) Reduction of prostaglandins synthesis at 50 µM in all treatment groups and reduction of cartilage degradation observed at 1 mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. |
| PMID:24168233 DOI:10.3109/03639045.2013.850704 |
| 2015 Drug development and industrial pharmacy |
| * In vitro evaluation of S-(+)-ibuprofen as drug candidate for intra-articular drug delivery system. |
| - Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13 days with LPS in combination with S-(+)-ibuprofen at 50 µM and 1 mM. S-(+)-ibuprofen (50 µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1 mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p = 0.0072), proteoglycans degradation by 35% (p = 0.0114) and expression of serum amyloid protein - the main protein induced upon LPS challenge - by 44% (p < 0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1 mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50 µM in all treatment groups and reduction of cartilage degradation observed at 1 mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. |
[
right
kwic]
(1)155  in |
(9)9 on |
(17)4 a |
(25)2 data |
| (2)48 *null* | (10)8 by |
(18)4 during |
(26)2 experimentally |
| (3)36 that |
(11)8 to |
(19)4 the |
(27)2 reduction |
| (4)19 for |
(12)8 when |
(20)3 variation |
(28)2 significant |
| (5)18 at |
(13)6 among |
(21)2 as |
(29)2 through |
| (6)16 between |
(14)6 following |
(22)2 changes |
(30)2 throughout |
| (7)11 with |
(15)5 after |
(23)2 clinical |
(31)2 up |
| (8)9 and |
(16)5 from |
(24)2 compared |
(32)2 using |
add keyword
--- WordNet output for observed ---