ELIZA

return kwic search for observed out of >500 occurrences
392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [no cache] 500 found

29) Contractility in response to a muscarinic receptor agonist, a nitric oxide precursor or electrical field stimulation was observed in all groups.

--- ABSTRACT ---

PMID:23913876 DOI:10.1002/term.1794

2015 Journal of tissue engineering and regenerative medicine

* Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa.

- Small intestinal submucosa (SIS) is a biodegradable collagen-rich matrix containing functional growth factors. We have previously reported encouraging outcomes for regeneration of an artificial defect in the rodent stomach using SIS grafts, although the muscular layer was diminutive. In this study, we investigated the feasibility of SIS in conjunction with mesenchymal stem cells (MSCs) for regeneration of the gastrointestinal tract. MSCs from the bone marrow of green fluorescence protein (GFP)-transgenic Sprague-Dawley (SD) rats were isolated and expanded ex vivo. A 1 cm whole-layer stomach defect in SD rats was repaired using: a plain SIS graft without MSCs (group 1, control); a plain SIS graft followed by intravenous injection of MSCs (group 2); a SIS graft co-cultured with MSCs (group 3); or a SIS sandwich containing an MSC sheet (group 4). Pharmacological, electrophysiological and immunohistochemical examination was performed to evaluate the regenerated stomach tissue. Contractility in response to a muscarinic receptor agonist, a nitric oxide precursor or electrical field stimulation was observed in all groups. SIS grafts seeded with MSCs (groups 3 and 4) appeared to support improved regeneration compared with SIS grafts not seeded with MSCs (groups 1 and 2), by enabling the development of well-structured smooth muscle layers of significantly increased length. GFP expression was detected in the regenerated interstitial tissue, with fibroblast-like cells in the seeded-SIS groups. SIS potently induced pharmacological and electrophysiological regeneration of the digestive tract, and seeded MSCs provided an enriched environment that supported tissue regeneration by the SIS graft in the engineered stomach.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to observed]

(1)155 in	(9)9 on	(17)4 a	(25)2 data
(2)48 null	(10)8 by	(18)4 during	(26)2 experimentally
(3)36 that	(11)8 to	(19)4 the	(27)2 reduction
(4)19 for	(12)8 when	(20)3 variation	(28)2 significant
(5)18 at	(13)6 among	(21)2 as	(29)2 through
(6)16 between	(14)6 following	(22)2 changes	(30)2 throughout
(7)11 with	(15)5 after	(23)2 clinical	(31)2 up
(8)9 and	(16)5 from	(24)2 compared	(32)2 using

add keyword

--- WordNet output for observed --- Overview of verb observe The verb observe has 9 senses (first 8 from tagged texts) 1. (39) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 2. (17) note, observe, mention, remark -- (make mention of; "She observed that his presentation took up too much time"; "They noted that it was a fine day to go sailing") 3. (12) note, take note, observe -- (observe with care or pay close attention to; "Take note of this chemical reaction") 4. (10) observe -- (watch attentively; "Please observe the reaction of these two chemicals") 5. (4) respect, honor, honour, abide by, observe -- (show respect towards; "honor your parents!") 6. (3) observe, celebrate, keep -- (behave as expected during of holidays or rites; "Keep the commandments"; "celebrate Christmas"; "Observe Yom Kippur") 7. (2) watch, observe, follow, watch over, keep an eye on -- (follow with the eyes or the mind; "Keep an eye on the baby, please!"; "The world is watching Sarajevo"; "She followed the men with the binoculars") 8. (1) observe, keep, maintain -- (stick to correctly or closely; "The pianist kept time with the metronome"; "keep count"; "I cannot keep track of all my employees") 9. observe, keep -- (conform one's action or practice to; "keep appointments"; "she never keeps her promises"; "We kept to the original conditions of the contract") Overview of adj observed The adj observed has 1 sense (first 1 from tagged texts) 1. (7) ascertained, discovered, observed -- (discovered or determined by scientific observation; "variation in the ascertained flux depends on a number of factors"; "the discovered behavior norms"; "discovered differences in achievement"; "no explanation for the observed phenomena") --- WordNet end ---