ELIZA

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392826 occurrences (No.45 in the rank) during 5 years in the PubMed. [no cache] 500 found

291) Therefore, no difference was observed between the treatments.

--- ABSTRACT ---

PMID:23615221 DOI:10.1111/vco.12033

2015 Veterinary and comparative oncology

* Pilot clinical study of carmustine associated with a lipid nanoemulsion in combination with vincristine and prednisone for the treatment of canine lymphoma.

- A lipid nanoemulsion (LDE) resembling low-density lipoprotein can target malignant tumours. In in vivo and clinical studies, association of chemotherapeutic agents to LDE decreased their toxicity and increased pharmacological action. Here, safety of LDE as carmustine carrier (50 mg m(-2) , intravenous) combined with vincristine and prednisone for the treatment of dogs with lymphoma was tested and compared with commercial carmustine with vincristine and prednisone. In five dogs from LDE-carmustine and six from commercial carmustine, complete remission was achieved (P > 0.05). Partial remission occurred in two dogs from each group. In both groups, the median progression-free intervals (119 and 199 days) and overall survival times (207 and 247 days) were equal. Neutropenia was observed in both groups, but no other major toxicities occurred. Therefore, no difference was observed between the treatments. LDE-carmustine was shown to be safe and effective in a drug combination protocol, which encourages larger studies to investigate the use of this novel formulation to treat canine lymphomas.

--- ABSTRACT END ---

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(1)155 in	(9)9 on	(17)4 a	(25)2 data
(2)48 null	(10)8 by	(18)4 during	(26)2 experimentally
(3)36 that	(11)8 to	(19)4 the	(27)2 reduction
(4)19 for	(12)8 when	(20)3 variation	(28)2 significant
(5)18 at	(13)6 among	(21)2 as	(29)2 through
(6)16 between	(14)6 following	(22)2 changes	(30)2 throughout
(7)11 with	(15)5 after	(23)2 clinical	(31)2 up
(8)9 and	(16)5 from	(24)2 compared	(32)2 using

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--- WordNet output for observed --- Overview of verb observe The verb observe has 9 senses (first 8 from tagged texts) 1. (39) detect, observe, find, discover, notice -- (discover or determine the existence, presence, or fact of; "She detected high levels of lead in her drinking water"; "We found traces of lead in the paint") 2. (17) note, observe, mention, remark -- (make mention of; "She observed that his presentation took up too much time"; "They noted that it was a fine day to go sailing") 3. (12) note, take note, observe -- (observe with care or pay close attention to; "Take note of this chemical reaction") 4. (10) observe -- (watch attentively; "Please observe the reaction of these two chemicals") 5. (4) respect, honor, honour, abide by, observe -- (show respect towards; "honor your parents!") 6. (3) observe, celebrate, keep -- (behave as expected during of holidays or rites; "Keep the commandments"; "celebrate Christmas"; "Observe Yom Kippur") 7. (2) watch, observe, follow, watch over, keep an eye on -- (follow with the eyes or the mind; "Keep an eye on the baby, please!"; "The world is watching Sarajevo"; "She followed the men with the binoculars") 8. (1) observe, keep, maintain -- (stick to correctly or closely; "The pianist kept time with the metronome"; "keep count"; "I cannot keep track of all my employees") 9. observe, keep -- (conform one's action or practice to; "keep appointments"; "she never keeps her promises"; "We kept to the original conditions of the contract") Overview of adj observed The adj observed has 1 sense (first 1 from tagged texts) 1. (7) ascertained, discovered, observed -- (discovered or determined by scientific observation; "variation in the ascertained flux depends on a number of factors"; "the discovered behavior norms"; "discovered differences in achievement"; "no explanation for the observed phenomena") --- WordNet end ---