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295512 occurrences (No.81 in the rank) during 5 years in the PubMed. [cache]

224) This assay demonstrates superiority over a solo DAP fluorescence-based assay as well as other reported methods, with excellent sensitivity and reduced testing time.

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PMID:33388845 DOI:10.1007/s00216-020-03104-7

2021 Analytical and bioanalytical chemistry

* Sensitive ratiometric fluorescence assay for detecting xanthine in serum based on the inner filter effect of enzyme-catalyzed oxidation products to silicon nanoparticles.

- A new type of fluorescent silicon nanoparticles (SiNPs) were prepared via a facile one-pot hydrothermal method by using N-[3-(trimethoxysilyl)propyl]-ethylenediamine (DAMO) and glucose as reagents, and were subsequently applied to construct a ratiometric fluorescence assay for sensitive and rapid determination of xanthine in human serum. Two catalytic oxidation reactions were employed to induce a fluorescence response of the testing system towards xanthine. Under the catalysis of xanthine oxidase (XOD), xanthine in serum samples was oxidized and produced hydrogen peroxide (H₂O₂). By utilizing o-phenylenediamine (OPD) as the substrate for horseradish peroxidase (HRP) in the presence of H₂O₂, fluorescent 2,3-diaminophenazine (DAP) was finally generated. A ratiometric fluorescence assay for xanthine was established by determining the ratio of the green-yellow fluorescence emission of DAP and the blue fluorescence emitted from SiNPs under the inner filter effect (IFE) of DAP. Instead of traditional multi-step procedures for adding reacting reagents to the testing solution, all the reaction reagents were mixed with serum samples in a single step for this assay to shorten the total reaction time. This assay demonstrates superiority over a solo DAP fluorescence-based assay as well as other reported methods, with excellent sensitivity and reduced testing time. The strategies proposed in this work for both synthesis and application of fluorescent SiNPs can be used in future fabrication of novel fluorescent probes, especially for sensing biological metabolites involved in H₂O₂-generation or consumption reactions.

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[frequency of next (right) word to over]

(1)135 the	(12)4 other	(23)2 50%	(34)2 health
(2)61 time	(13)3 recent	(24)2 59	(35)2 in
(3)37 a	(14)3 standard	(25)2 60%	(36)2 left
(4)17 time,	(15)3 three	(26)2 IP1	(37)2 longer
(5)12 half	(16)3 two	(27)2 M1	(38)2 multiple
(6)7 an	(17)2 null	(28)2 age	(39)2 of
(7)7 their	(18)2 18	(29)2 all	(40)2 one
(8)6 10	(19)2 2	(30)2 design	(41)2 or
(9)6 and	(20)2 20,000	(31)2 existing	(42)2 several
(10)4 200	(21)2 3,000	(32)2 extended	(43)2 six
(11)4 80%	(22)2 40	(33)2 from

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--- WordNet output for over --- =>1.超えて, 一面に, 移って, 始めから終わりまで, 終わって, を支配して, の間, しながら, 倒れて, の上に, を覆って, を越えて, の向こう側に, より多く, 2.もう一度, 繰り返して Overview of noun over The noun over has 1 sense (no senses from tagged texts) 1. over -- ((cricket) the division of play during which six balls are bowled at the batsman by one player from the other team from the same end of the pitch) Overview of adj over The adj over has 1 sense (first 1 from tagged texts) 1. (21) complete, concluded, ended, over, all over, terminated -- (having come or been brought to a conclusion; "the harvesting was complete"; "the affair is over, ended, finished"; "the abruptly terminated interview") Overview of adv over The adv over has 5 senses (first 3 from tagged texts) 1. (23) over -- (at or to a point across intervening space etc.; "come over and see us some time"; "over there") 2. (2) over -- (throughout an area; "he is known the world over") 3. (1) over, o'er -- (throughout a period of time; "stay over the weekend") 4. over -- (beyond the top or upper surface or edge; forward from an upright position; "a roof that hangs over";) 5. all over, over -- (over the entire area; "the wallpaper was covered all over with flowers"; "she ached all over"; "everything was dusted over with a fine layer of soot") --- WordNet end ---