ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found
14) Specificity of the anti-A-SUCL-β antiserum was verified by the absence of labeling in fibroblasts from a patient with a complete deletion of SUCLA2.
--- ABSTRACT ---
PMID:24085565 DOI:10.1007/s00429-013-0643-2
2015 Brain structure & function
* Exclusive neuronal expression of SUCLA2 in the human brain.
- SUCLA2 encodes the ATP-forming β subunit (A-SUCL-β) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness and lesions in the basal ganglia. Despite the distinct brain pathology associated with SUCLA2 mutations, the precise localization of SUCLA2 protein has never been investigated. Here, we show that immunoreactivity of A-SUCL-β in surgical human cortical tissue samples was present exclusively in neurons, identified by their morphology and visualized by double labeling with a fluorescent Nissl dye. A-SUCL-β immunoreactivity co-localized >99 % with that of the d subunit of the mitochondrial F0-F1 ATP synthase. Specificity of the anti-A-SUCL-β antiserum was verified by the absence of labeling in fibroblasts from a patient with a complete deletion of SUCLA2. A-SUCL-β immunoreactivity was absent in glial cells, identified by antibodies directed against the glial markers GFAP and S100. Furthermore, in situ hybridization histochemistry demonstrated that SUCLA2 mRNA was present in Nissl-labeled neurons but not glial cells labeled with S100. Immunoreactivity of the GTP-forming β subunit (G-SUCL-β) encoded by SUCLG2, or in situ hybridization histochemistry for SUCLG2 mRNA could not be demonstrated in either neurons or astrocytes. Western blotting of post mortem brain samples revealed minor G-SUCL-β immunoreactivity that was, however, not upregulated in samples obtained from diabetic versus non-diabetic patients, as has been described for murine brain. Our work establishes that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex.
--- ABSTRACT END ---
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[frequency of next (right) word to patient]
(1)52 with (17)4 MSCs (33)3 subsequently (49)2 motivation
(2)30 was (18)4 education (34)2 Education (50)2 of
(3)20 *null* (19)4 presenting (35)2 achieved (51)2 outcome
(4)18 and (20)4 required (36)2 age (52)2 pain
(5)15 had (21)4 safety (37)2 as (53)2 population
(6)12 who (22)4 to (38)2 assessment (54)2 population,
(7)11 care (23)4 were (39)2 being (55)2 received
(8)7 is (24)3 characteristics (40)2 can (56)2 remained
(9)7 survival (25)3 comfort (41)2 computational (57)2 remains
(10)7 underwent (26)3 died (42)2 data (58)2 reported
(11)6 developed (27)3 group (43)2 days (59)2 response
(12)6 outcomes (28)3 information (44)2 empowerment (60)2 responses
(13)6 satisfaction (29)3 life (45)2 factors, (61)2 symptoms
(14)5 groups (30)3 on (46)2 for (62)2 the
(15)5 in (31)3 postoperative (47)2 immunomigration
(16)5 presented (32)3 referral (48)2 including

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---