* [Resistance to acenocoumarol revealing a missense mutation of the vitamin K epoxyde reductase VKORC1: a case report].
- A significant proportion of the interindividual variability of the response to vitamin K antagonist (VKA) treatment has been associated with genetic factors. Genetic variations affecting the vitamin K epoxide reductase complex subunit 1 (VKORC1) are associated with hypersensitivity or rarely with resistance to VKA. We report the case of a black women patient who presents a resistance to acenocoumarol. Despite the use of high doses of acenocoumarol (114 mg/week) for the treatment of recurrent pulmonary embolism, the International Normalized Ratio was below the therapeutic target. This resistance to acenocoumarol was confirmed by the identification of a missense mutation Val66Met of the vitamin K epoxide reductase.
=>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者
Overview of noun patient
The noun patient has 2 senses (first 1 from tagged texts)
1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown
rapidly")
2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but
is directly involved in or affected by the happening denoted by the verb in the clause)
Overview of adj patient
The adj patient has 1 sense (first 1 from tagged texts)
1. (3) patient -- (enduring trying circumstances with even temper or characterized by such
endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist";
"please be patient")
--- WordNet end ---