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return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found

249) The patient died at age 18 years due to pneumonia and tension pneumothorax.

--- ABSTRACT ---

PMID:23010537 DOI:10.1016/j.jmii.2012.07.004

2015 Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

* X-linked hyper-IgM syndrome with CD40LG mutation: two case reports and literature review in Taiwanese patients.

- Hyper-IgM syndrome (HIGM) is a rare primary immunodeficiency disorder characterized by elevated or normal serum IgM and decreased IgG, IgA, and IgE due to defective immunoglobulin class switching. X-linked HIGM (XHIGM, HIGM1) is the most frequent type, is caused by mutations in the CD40 ligand gene, and is regarded as a combined T and B immunodeficiency. We report an 18-year-old male who was diagnosed initially with hypogammaglobulinemia in infancy, but developed repeated pneumonia, sepsis, cellulitis, perianal abscess, pericarditis, and bronchiectasis despite regular intravenous immunoglobulin replacement therapy. The patient died at age 18 years due to pneumonia and tension pneumothorax. Mutation analysis revealed CD40L gene mutation within Exon 5 at nucleotide position 476 (cDNA 476G > A). This nonsense mutation predicted a tryptophan codon (TGG) change to a stop codon (TGA) at position 140 (W140X), preventing CD40L protein expression. Sequence analysis in the family confirmed a de novo mutation. The second case of 6-month-old male infant presented as Pneumocystis jiroveci pneumonia and acute respiratory distress syndrome. Gene analysis of the CD40L gene revealed G to C substitution in Intron 4 (c.409 + 5G > C) and mother was a carrier. Hematopoietic stem cell transplantation, the only cure for XHIGM, was arranged in the second case.

--- ABSTRACT END ---

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[frequency of next (right) word to patient]

(1)52 with	(17)4 MSCs	(33)3 subsequently	(49)2 motivation
(2)30 was	(18)4 education	(34)2 Education	(50)2 of
(3)20 null	(19)4 presenting	(35)2 achieved	(51)2 outcome
(4)18 and	(20)4 required	(36)2 age	(52)2 pain
(5)15 had	(21)4 safety	(37)2 as	(53)2 population
(6)12 who	(22)4 to	(38)2 assessment	(54)2 population,
(7)11 care	(23)4 were	(39)2 being	(55)2 received
(8)7 is	(24)3 characteristics	(40)2 can	(56)2 remained
(9)7 survival	(25)3 comfort	(41)2 computational	(57)2 remains
(10)7 underwent	(26)3 died	(42)2 data	(58)2 reported
(11)6 developed	(27)3 group	(43)2 days	(59)2 response
(12)6 outcomes	(28)3 information	(44)2 empowerment	(60)2 responses
(13)6 satisfaction	(29)3 life	(45)2 factors,	(61)2 symptoms
(14)5 groups	(30)3 on	(46)2 for	(62)2 the
(15)5 in	(31)3 postoperative	(47)2 immunomigration
(16)5 presented	(32)3 referral	(48)2 including

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---