ELIZA

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]

275) We report here that several RORγ antagonists/inverse agonists including XY018 and compound 31 were orally effective in potent inhibition of the growth of tumor models including patient-derived xenograft (PDX) tumors.

--- ABSTRACT ---

PMID:33916325 DOI:10.3390/cancers13071672

2021 Cancers

* Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling.

- Metastatic castration-resistant prostate cancer (mCRPC) is a highly aggressive disease with few therapeutic options. Hyperactive androgen receptor (AR) signaling plays a key role in CRPC progression. Previously, we identified RAR-related orphan receptor gamma (RORγ) as a novel key driver of AR gene overexpression and increased AR signaling. We report here that several RORγ antagonists/inverse agonists including XY018 and compound 31 were orally effective in potent inhibition of the growth of tumor models including patient-derived xenograft (PDX) tumors. RORγ controls the expression of multiple aggressive-tumor gene programs including those of epithelial-mesenchymal transition (EMT) and invasion. We found that PDZ binding kinase (PBK), a serine/threonine kinase, is a downstream target of RORγ that exerts the cellular effects. Alterations of RORγ expression or function significantly downregulated the mRNA and protein level of PBK. Our further analyses demonstrated that elevated PBK associates with and stabilizes RORγ and AR proteins, thus constituting novel, interlocked feed-forward loops in hyperactive AR and RORγ signaling. Indeed, dual inhibition of RORγ and PBK synergistically inhibited the expression and function of RORγ, AR, and AR-V7, and the growth and survival of CRPC cells. Therefore, our study provided a promising, new strategy for treatment of advanced forms of prostate cancer.

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[frequency of next (right) word to patient]

(1)34 and	(20)4 communication	(39)3 prognosis	(58)2 interactions
(2)28 outcomes	(21)4 experiences	(40)3 satisfaction,	(59)2 monitoring,
(3)26 care	(22)4 knowledge	(41)3 stratification	(60)2 outcomes,
(4)13 safety	(23)4 outcome	(42)3 who	(61)2 outcomes;
(5)12 with	(24)3 access	(43)3 xenograft	(62)2 participation
(6)10 null	(25)3 care,	(44)2 cell	(63)2 perceptions
(7)9 populations	(26)3 characteristics	(45)2 choice	(64)2 perspectives
(8)7 data	(27)3 education	(46)2 classification	(65)2 plasma
(9)7 population	(28)3 group	(47)2 condition	(66)2 population,
(10)7 satisfaction	(29)3 groups	(48)2 costs	(67)2 portals
(11)7 was	(30)3 had	(49)2 demographics,	(68)2 preferences
(12)6 samples	(31)3 is	(50)2 engagement	(69)2 reported
(13)5 characteristics,	(32)3 language	(51)2 expectations	(70)2 samples,
(14)5 cohort	(33)3 medical	(52)2 experience	(71)2 suffering
(15)5 factors	(34)3 monitoring	(53)2 fibroblasts	(72)2 survival,
(16)5 in	(35)3 needs	(54)2 goals	(73)2 that
(17)5 management	(36)3 of	(55)2 groups,	(74)2 to
(18)5 navigation	(37)3 or	(56)2 health	(75)2 tumors
(19)5 survival	(38)3 perspective,	(57)2 information	(76)2 underwent

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---