ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]
278) To understand mechanisms of platinum resistance and identify potential therapeutic targets in resistant HGSOC, we generated a data resource composed of dynamic (±carboplatin) protein, post-translational modification, and RNA sequencing (RNA-seq) profiles from intra-patient cell line pairs derived from 3 HGSOC patients before and after acquiring platinum resistance.
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PMID:35028612 DOI:10.1016/j.xcrm.2021.100471
2021 Cell reports. Medicine
* Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer.
- Resistance to platinum compounds is a major determinant of patient survival in high-grade serous ovarian cancer (HGSOC). To understand mechanisms of platinum resistance and identify potential therapeutic targets in resistant HGSOC, we generated a data resource composed of dynamic (±carboplatin) protein, post-translational modification, and RNA sequencing (RNA-seq) profiles from intra-patient cell line pairs derived from 3 HGSOC patients before and after acquiring platinum resistance. These profiles reveal extensive responses to carboplatin that differ between sensitive and resistant cells. Higher fatty acid oxidation (FAO) pathway expression is associated with platinum resistance, and both pharmacologic inhibition and CRISPR knockout of carnitine palmitoyltransferase 1A (CPT1A), which represents a rate limiting step of FAO, sensitize HGSOC cells to platinum. The results are further validated in patient-derived xenograft models, indicating that CPT1A is a candidate therapeutic target to overcome platinum resistance. All multiomic data can be queried via an intuitive gene-query user interface (https://sites.google.com/view/ptrc-cell-line).
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(1)34 and (20)4 communication (39)3 prognosis (58)2 interactions
(2)28 outcomes (21)4 experiences (40)3 satisfaction, (59)2 monitoring,
(3)26 care (22)4 knowledge (41)3 stratification (60)2 outcomes,
(4)13 safety (23)4 outcome (42)3 who (61)2 outcomes;
(5)12 with (24)3 access (43)3 xenograft (62)2 participation
(6)10 *null* (25)3 care, (44)2 cell (63)2 perceptions
(7)9 populations (26)3 characteristics (45)2 choice (64)2 perspectives
(8)7 data (27)3 education (46)2 classification (65)2 plasma
(9)7 population (28)3 group (47)2 condition (66)2 population,
(10)7 satisfaction (29)3 groups (48)2 costs (67)2 portals
(11)7 was (30)3 had (49)2 demographics, (68)2 preferences
(12)6 samples (31)3 is (50)2 engagement (69)2 reported
(13)5 characteristics, (32)3 language (51)2 expectations (70)2 samples,
(14)5 cohort (33)3 medical (52)2 experience (71)2 suffering
(15)5 factors (34)3 monitoring (53)2 fibroblasts (72)2 survival,
(16)5 in (35)3 needs (54)2 goals (73)2 that
(17)5 management (36)3 of (55)2 groups, (74)2 to
(18)5 navigation (37)3 or (56)2 health (75)2 tumors
(19)5 survival (38)3 perspective, (57)2 information (76)2 underwent

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---