ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found
321) In addition, SjS patient plasma samples were evaluated for sMer levels via ELISA, and sMer levels were correlated to disease manifestations.
--- ABSTRACT ---
PMID:34575873 DOI:10.3390/ijms22189711
2021 International journal of molecular sciences
* Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor.
- Sjögren's syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands in which the involvement of the innate immune system is largely uncharacterized. Mer signaling has been found to be protective in several autoimmune diseases but remains unstudied in SjS. Here, we investigated the role of Mer signaling in SjS. Mer knockout (MerKO) mice were examined for SjS disease criteria. SjS-susceptible (SjSS) C57BL/6.NOD-Aec1Aec2 mice were assessed for defective Mer signaling outcomes, soluble Mer (sMer) levels, A disintegrin and metalloprotease 17 (ADAM17) activity, and Rac1 activation. In addition, SjS patient plasma samples were evaluated for sMer levels via ELISA, and sMer levels were correlated to disease manifestations. MerKO mice developed submandibular gland (SMG) lymphocytic infiltrates, SMG apoptotic cells, anti-nuclear autoantibodies (ANA), and reduced saliva flow. Mer signaling outcomes were observed to be diminished in SjSS mice, as evidenced by reduced Rac1 activation in SjSS mice macrophages in response to apoptotic cells and impaired efferocytosis. Increased sMer was also detected in SjSS mouse sera, coinciding with higher ADAM17 activity, the enzyme responsible for cleavage and inactivation of Mer. sMer levels were elevated in patient plasma and positively correlated with focus scores, ocular staining scores, rheumatoid factors, and anti-Ro60 levels. Our data indicate that Mer plays a protective role in SjS, similar to other autoimmune diseases. Furthermore, we suggest a series of events where enhanced ADAM17 activity increases Mer inactivation and depresses Mer signaling, thus removing protection against the loss of self-tolerance and the onset of autoimmune disease in SjSS mice.
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[frequency of next (right) word to patient]
(1)34 and (20)4 communication (39)3 prognosis (58)2 interactions
(2)28 outcomes (21)4 experiences (40)3 satisfaction, (59)2 monitoring,
(3)26 care (22)4 knowledge (41)3 stratification (60)2 outcomes,
(4)13 safety (23)4 outcome (42)3 who (61)2 outcomes;
(5)12 with (24)3 access (43)3 xenograft (62)2 participation
(6)10 *null* (25)3 care, (44)2 cell (63)2 perceptions
(7)9 populations (26)3 characteristics (45)2 choice (64)2 perspectives
(8)7 data (27)3 education (46)2 classification (65)2 plasma
(9)7 population (28)3 group (47)2 condition (66)2 population,
(10)7 satisfaction (29)3 groups (48)2 costs (67)2 portals
(11)7 was (30)3 had (49)2 demographics, (68)2 preferences
(12)6 samples (31)3 is (50)2 engagement (69)2 reported
(13)5 characteristics, (32)3 language (51)2 expectations (70)2 samples,
(14)5 cohort (33)3 medical (52)2 experience (71)2 suffering
(15)5 factors (34)3 monitoring (53)2 fibroblasts (72)2 survival,
(16)5 in (35)3 needs (54)2 goals (73)2 that
(17)5 management (36)3 of (55)2 groups, (74)2 to
(18)5 navigation (37)3 or (56)2 health (75)2 tumors
(19)5 survival (38)3 perspective, (57)2 information (76)2 underwent

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---