ELIZA

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1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found

338) In this study we investigated RD deletions in 30 squamous cell carcinoma of the head and neck (SCCHN) and the patient-matched High At-Risk Mucosa specimens (HARM, "phenotypically normal" tissues neighboring SCCHN foci but beyond the surgical resection margin).

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PMID:24302590 DOI:10.1002/mc.22119

2015 Molecular carcinogenesis

* Alterations in RD(INK4/ARF) -mediated en bloc regulation of the INK4-ARF locus in human squamous cell carcinoma of the head and neck.

- The presence of RD(INK4/ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such upregulation can be repressed through interactions between RD and oncoproteins CDC6 and BMI1, little is known about the involvement of RD in cancer. In this study we investigated RD deletions in 30 squamous cell carcinoma of the head and neck (SCCHN) and the patient-matched High At-Risk Mucosa specimens (HARM, "phenotypically normal" tissues neighboring SCCHN foci but beyond the surgical resection margin). RD was deleted (homozygously/heterozygously) in SCCHN and HARM at the incidence of 36.7% (11/30) and 13.3% (4/30), respectively. In comparison, no RD deletion was detected in 26 oral buccal brush biopsy specimens from healthy donors. Both p16 and p14 were lowly expressed in SCCHN and HARM, and their mRNA expression levels were positively associated with each other (P < 0.01). Moreover, BMI1 was highly expressed in both SCCHN and HARM, and BMI1 overexpression was associated with p16 downregulation in SCCHN (P < 0.05). These results indicate that RD deletion and BMI1 overexpression frequently occur in the early stage of oral carcinogenesis and BMI1 overexpression may downregulate the transcription of p16 and p14 through interfering with RD.

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(1)52 with	(17)4 MSCs	(33)3 subsequently	(49)2 motivation
(2)30 was	(18)4 education	(34)2 Education	(50)2 of
(3)20 null	(19)4 presenting	(35)2 achieved	(51)2 outcome
(4)18 and	(20)4 required	(36)2 age	(52)2 pain
(5)15 had	(21)4 safety	(37)2 as	(53)2 population
(6)12 who	(22)4 to	(38)2 assessment	(54)2 population,
(7)11 care	(23)4 were	(39)2 being	(55)2 received
(8)7 is	(24)3 characteristics	(40)2 can	(56)2 remained
(9)7 survival	(25)3 comfort	(41)2 computational	(57)2 remains
(10)7 underwent	(26)3 died	(42)2 data	(58)2 reported
(11)6 developed	(27)3 group	(43)2 days	(59)2 response
(12)6 outcomes	(28)3 information	(44)2 empowerment	(60)2 responses
(13)6 satisfaction	(29)3 life	(45)2 factors,	(61)2 symptoms
(14)5 groups	(30)3 on	(46)2 for	(62)2 the
(15)5 in	(31)3 postoperative	(47)2 immunomigration
(16)5 presented	(32)3 referral	(48)2 including

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---