ELIZA

return kwic search for patient out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [no cache] 500 found

355) However, most genetic mouse models lack striking neurodegeneration that has been found in patient brains.

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PMID:24048953 DOI:10.1007/7854_2013_246

2015 Current topics in behavioral neurosciences

* Large Animal Models of Huntington's Disease.

- Huntington's disease is caused by the expansion of a polyglutamine repeat (>37 glutamines) in the disease protein huntingtin, which results in preferential neuronal loss in distinct brain regions. Mutant huntingtin causes late-onset neurological symptoms in patients in middle life, though the expression of mutant huntingtin is ubiquitous from early life. Thus, it is important to understand why mutant huntingtin selectively causes neuronal loss in an age-dependent manner. Transgenic animal models have been essential tools for uncovering the pathogenesis and therapeutic targets of neurodegenerative diseases. Genetic mouse models have been investigated extensively and have revealed the common pathological hallmark of age-dependent formation of aggregates or inclusions consisting of misfolded proteins. However, most genetic mouse models lack striking neurodegeneration that has been found in patient brains. Since there are considerable species differences between small and large animals, large animal models of Huntington's disease may allow one to identify the pathological features that are more similar to those in patients and also help uncover more effective therapeutic targets. This chapter will focus on the important findings from large animal models of Huntington's disease and discusses the use of large animal models to investigate the pathogenesis of Huntington's disease and develop new therapeutic strategies.

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(1)52 with	(17)4 MSCs	(33)3 subsequently	(49)2 motivation
(2)30 was	(18)4 education	(34)2 Education	(50)2 of
(3)20 null	(19)4 presenting	(35)2 achieved	(51)2 outcome
(4)18 and	(20)4 required	(36)2 age	(52)2 pain
(5)15 had	(21)4 safety	(37)2 as	(53)2 population
(6)12 who	(22)4 to	(38)2 assessment	(54)2 population,
(7)11 care	(23)4 were	(39)2 being	(55)2 received
(8)7 is	(24)3 characteristics	(40)2 can	(56)2 remained
(9)7 survival	(25)3 comfort	(41)2 computational	(57)2 remains
(10)7 underwent	(26)3 died	(42)2 data	(58)2 reported
(11)6 developed	(27)3 group	(43)2 days	(59)2 response
(12)6 outcomes	(28)3 information	(44)2 empowerment	(60)2 responses
(13)6 satisfaction	(29)3 life	(45)2 factors,	(61)2 symptoms
(14)5 groups	(30)3 on	(46)2 for	(62)2 the
(15)5 in	(31)3 postoperative	(47)2 immunomigration
(16)5 presented	(32)3 referral	(48)2 including

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--- WordNet output for patient --- =>がまん強い, 忍耐強い, 辛抱強い, 根気よく働く, 患者, 病人, 忠者 Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) Overview of adj patient The adj patient has 1 sense (first 1 from tagged texts) 1. (3) patient -- (enduring trying circumstances with even temper or characterized by such endurance; "a patient smile"; "was patient with the children"; "an exact and patient scientist"; "please be patient") --- WordNet end ---