5) His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection. |
PMID:23680261 DOI:10.1016/j.pedneo.2013.04.001 |
2015 Pediatrics and neonatology |
* Successful Unrelated Cord Blood Stem Cell Transplantation in an X-linked Chronic Granulomatous Disease Patient with Disseminated BCG-induced Infection. |
- A 19-month-old boy with chronic granulomatous disease (CGD) received umbilical cord blood transplantation (UCBT) from an unrelated donor after experiencing a life-threatening disseminated Bacillus Calmette-Guérin infection. After busulfan and cyclophosphamide conditioning, we performed a 5/6-matched UCBT. Engraftment and mixed chimerism was 100% in peripheral blood, and 100% of his neutrophils had normal oxidative burst activity on day 17. The patient is now 3 years old, free from infection, and growing well. To our knowledge, this is the second case of CGD treated with UCBT in Taiwan. His successful outcome illustrates that UCBT in a patient with CGD should be considered early if a human leukocyte antigen-matched donor is not available or the patient has just recovered from a severe infection. |
(1)52 with | (17)4 MSCs | (33)3 subsequently | (49)2 motivation |
(2)30 was | (18)4 education | (34)2 Education | (50)2 of |
(3)20 *null* | (19)4 presenting | (35)2 achieved | (51)2 outcome |
(4)18 and | (20)4 required | (36)2 age | (52)2 pain |
(5)15 had | (21)4 safety | (37)2 as | (53)2 population |
(6)12 who | (22)4 to | (38)2 assessment | (54)2 population, |
(7)11 care | (23)4 were | (39)2 being | (55)2 received |
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(10)7 underwent | (26)3 died | (42)2 data | (58)2 reported |
(11)6 developed | (27)3 group | (43)2 days | (59)2 response |
(12)6 outcomes | (28)3 information | (44)2 empowerment | (60)2 responses |
(13)6 satisfaction | (29)3 life | (45)2 factors, | (61)2 symptoms |
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(15)5 in | (31)3 postoperative | (47)2 immunomigration | |
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