ELIZA

return kwic search for patients out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]

194) The underlying drivers of this immune dysfunction remain elusive, and there are no prognostic markers to identify at-risk patients.

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PMID:34576246 DOI:10.3390/ijms221810083

2021 International journal of molecular sciences

* Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.

- Severe burn injury is a devastating form of trauma that results in persistent immune dysfunction with associated morbidity and mortality. The underlying drivers of this immune dysfunction remain elusive, and there are no prognostic markers to identify at-risk patients. Extracellular vesicles (EVs) are emerging as drivers of immune dysfunction as well as biomarkers. We investigated if EVs after burn injury promote macrophage activation and assessed if EV contents can predict length of hospital stay. EVs isolated early from mice that received a 20% total body surface area (TBSA) burn promoted proinflammatory responses in cultured splenic macrophages. Unbiased LC-MS/MS proteomic analysis of early EVs (<72 h post-injury) from mice and humans showed some similarities including enrichment of acute phase response proteins such as CRP and SAA1. Semi-unbiased assessment of early human burn patient EVs found alterations consistent with increased proinflammatory signaling and loss of inhibition of CRP expression. In a sample of 50 patients with large burn injury, EV SAA1 and CRP were correlated with TBSA injury in both sexes and were correlated with length of hospital stay in women. These findings suggest that EVs are drivers of immune responses after burn injury and their content may predict hospital course.

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[frequency of next (right) word to patients]

(1)150 with	(10)6 are	(19)4 the	(28)2 following
(2)63 null	(11)5 diagnosed	(20)3 but	(29)2 from
(3)30 and	(12)5 experience	(21)3 by	(30)2 on
(4)19 were	(13)5 have	(22)3 compared	(31)2 predicted
(5)16 in	(14)4 affected	(23)3 demonstrated	(32)2 presented
(6)11 who	(15)4 at	(24)3 developed	(33)2 received
(7)9 had	(16)4 may	(25)3 during	(34)2 respond
(8)8 to	(17)4 receiving	(26)2 as	(35)2 showed
(9)8 undergoing	(18)4 that	(27)2 can	(36)2 suggesting

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---