ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients out of >500 occurrences
1057411 occurrences (No.2 in the rank) during 5 years in the PubMed. [cache]
430) Our evaluation of retinal tissue from FTLD-Tau patients confirms ONL loss seen antemortem by OCT.
--- ABSTRACT ---
PMID:34794500 DOI:10.1186/s40478-021-01290-8
2021 Acta neuropathologica communications
* Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau.
- Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical coherence tomography (OCT) among patients considered to have a frontotemporal degeneration tauopathy (FTLD-Tau). Our objective was to determine if postmortem retinal tissue from FTLD-Tau patients demonstrates ONL loss observed antemortem on OCT. Two probable FTLD-Tau patients that were deeply phenotyped by clinical and genetic testing were imaged with OCT and followed to autopsy. Postmortem brain and retinal tissue were evaluated by a neuropathologist and ocular pathologist, respectively, masked to diagnosis. OCT findings were correlated with retinal histology. The two patients had autopsy-confirmed FTLD-Tau neuropathology and had antemortem OCT measurements showing ONL thinning (66.9 μm, patient #1; 74.9 μm, patient #2) below the 95% confidence interval of normal limits (75.1-120.7 μm) in our healthy control cohort. Postmortem, retinal tissue from both patients demonstrated loss of nuclei in the ONL, matching ONL loss visualized on antemortem OCT. Nuclei counts from each area of ONL loss (2 - 3 nuclei per column) seen in patient eyes were below the 95% confidence interval (4 - 8 nuclei per column for ONL) of 3 normal control retinas analyzed at the same location. Our evaluation of retinal tissue from FTLD-Tau patients confirms ONL loss seen antemortem by OCT. Continued investigation of ONL thinning as a biomarker that may distinguish FTLD-Tau from other dementias is warranted.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to patients]
(1)150 with (10)6 are (19)4 the (28)2 following
(2)63 *null* (11)5 diagnosed (20)3 but (29)2 from
(3)30 and (12)5 experience (21)3 by (30)2 on
(4)19 were (13)5 have (22)3 compared (31)2 predicted
(5)16 in (14)4 affected (23)3 demonstrated (32)2 presented
(6)11 who (15)4 at (24)3 developed (33)2 received
(7)9 had (16)4 may (25)3 during (34)2 respond
(8)8 to (17)4 receiving (26)2 as (35)2 showed
(9)8 undergoing (18)4 that (27)2 can (36)2 suggesting

add keyword

--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---