ELIZA

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]

123) Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β.

--- ABSTRACT ---

PMID:34413139 DOI:10.1126/sciimmunol.abl4340

2021 Science immunology

* Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

- Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to patients with]

(1)14 a	(26)3 PAH	(51)2 IgAn	(76)2 neurological
(2)14 severe	(27)3 PTB	(52)2 MIS-C	(77)2 no
(3)12 COVID-19	(28)3 SB	(53)2 MS,	(78)2 or
(4)10 cancer	(29)3 and	(54)2 PH,	(79)2 pancreatic
(5)10 chronic	(30)3 autonomic	(55)2 TSC	(80)2 pre-existing
(6)8 diabetes	(31)3 clinical	(56)2 UWS	(81)2 prolonged
(7)7 acute	(32)3 dysphagia	(57)2 accuracies	(82)2 psoriasis
(8)6 relapsed	(33)3 epilepsy	(58)2 ankylosing	(83)2 pulmonary
(9)5 AN	(34)3 idiopathic	(59)2 any	(84)2 resected
(10)5 MDD	(35)3 inflammatory	(60)2 cerebellar	(85)2 respiratory
(11)5 T2DM	(36)3 newly	(61)2 community-based	(86)2 rheumatoid
(12)5 advanced	(37)3 recurrent	(62)2 comorbidities	(87)2 schizophrenia
(13)5 lipoedema	(38)3 uncontrolled	(63)2 drug-resistant	(88)2 shared
(14)4 AD	(39)2 16p11.2	(64)2 heart	(89)2 special
(15)4 IBD	(40)2 ALL	(65)2 hemorrhagic	(90)2 spondyloarthritis
(16)4 breast	(41)2 ALS	(66)2 high	(91)2 stage
(17)4 chorea	(42)2 AML	(67)2 high-risk	(92)2 suspected
(18)4 critical	(43)2 ASD	(68)2 known	(93)2 symptomatic
(19)4 low	(44)2 BM	(69)2 locally	(94)2 the
(20)3 ARDS	(45)2 CHB	(70)2 lung	(95)2 these
(21)3 CKD	(46)2 COVID-19,	(71)2 mIDH1	(96)2 treatment-resistant
(22)3 CLL	(47)2 CRC	(72)2 major	(97)2 tuberculosis
(23)3 HGSOC	(48)2 CVDRF	(73)2 metastatic
(24)3 ILD	(49)2 HIV	(74)2 mild
(25)3 MD	(50)2 IIM	(75)2 neurologic

add keyword

--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---