ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]
150) Furthermore, CALHM1/2 were upregulated in freshly isolated PA from rats with monocrotaline (MCT)-induced PH and in primary cultured PASMC from patients with PAH in comparison to normal controls.
--- ABSTRACT ---
PMID:34408668 DOI:10.3389/fphys.2021.714785
2021 Frontiers in physiology
* Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.
- Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in patients with pulmonary arterial hypertension (PAH). Pulmonary artery smooth muscle cell contractile-to-proliferative phenotypical transition is a process that promotes pulmonary vascular remodeling. A rise in cytosolic Ca2+ concentration [(Ca2+) cyt ] in PASMCs is a trigger for pulmonary vasoconstriction and a stimulus for pulmonary vascular remodeling. Here, we report that the calcium homeostasis modulator (CALHM), a Ca2+ (and ATP) channel that is allosterically regulated by voltage and extracellular Ca2+, is upregulated during the PASMC contractile-to-proliferative phenotypical transition. Protein expression of CALHM1/2 in primary cultured PASMCs in media containing serum and growth factors (proliferative PASMC) was significantly greater than in freshly isolated PA (contractile PASMC) from the same rat. Upregulated CALHM1/2 in proliferative PASMCs were associated with an increased ratio of pAKT/AKT and pmTOR/mTOR and an increased expression of the cell proliferation marker PCNA, whereas serum starvation and rapamycin significantly downregulated CALHM1/2. Furthermore, CALHM1/2 were upregulated in freshly isolated PA from rats with monocrotaline (MCT)-induced PH and in primary cultured PASMC from patients with PAH in comparison to normal controls. Intraperitoneal injection of CGP 37157 (0.6 mg/kg, q8H), a non-selective blocker of CALHM channels, partially reversed established experimental PH. These data suggest that CALHM upregulation is involved in PASMC contractile-to-proliferative phenotypical transition. Ca2+ influx through upregulated CALHM1/2 may play an important role in the transition of sustained vasoconstriction to excessive vascular remodeling in PAH or precapillary PH. Calcium homeostasis modulator could potentially be a target to develop novel therapies for PAH.
--- ABSTRACT END ---
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[frequency of next (right) word to patients with]
(1)14 a (26)3 PAH (51)2 IgAn (76)2 neurological
(2)14 severe (27)3 PTB (52)2 MIS-C (77)2 no
(3)12 COVID-19 (28)3 SB (53)2 MS, (78)2 or
(4)10 cancer (29)3 and (54)2 PH, (79)2 pancreatic
(5)10 chronic (30)3 autonomic (55)2 TSC (80)2 pre-existing
(6)8 diabetes (31)3 clinical (56)2 UWS (81)2 prolonged
(7)7 acute (32)3 dysphagia (57)2 accuracies (82)2 psoriasis
(8)6 relapsed (33)3 epilepsy (58)2 ankylosing (83)2 pulmonary
(9)5 AN (34)3 idiopathic (59)2 any (84)2 resected
(10)5 MDD (35)3 inflammatory (60)2 cerebellar (85)2 respiratory
(11)5 T2DM (36)3 newly (61)2 community-based (86)2 rheumatoid
(12)5 advanced (37)3 recurrent (62)2 comorbidities (87)2 schizophrenia
(13)5 lipoedema (38)3 uncontrolled (63)2 drug-resistant (88)2 shared
(14)4 AD (39)2 16p11.2 (64)2 heart (89)2 special
(15)4 IBD (40)2 ALL (65)2 hemorrhagic (90)2 spondyloarthritis
(16)4 breast (41)2 ALS (66)2 high (91)2 stage
(17)4 chorea (42)2 AML (67)2 high-risk (92)2 suspected
(18)4 critical (43)2 ASD (68)2 known (93)2 symptomatic
(19)4 low (44)2 BM (69)2 locally (94)2 the
(20)3 ARDS (45)2 CHB (70)2 lung (95)2 these
(21)3 CKD (46)2 COVID-19, (71)2 mIDH1 (96)2 treatment-resistant
(22)3 CLL (47)2 CRC (72)2 major (97)2 tuberculosis
(23)3 HGSOC (48)2 CVDRF (73)2 metastatic
(24)3 ILD (49)2 HIV (74)2 mild
(25)3 MD (50)2 IIM (75)2 neurologic

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---