ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [no cache] 500 found
168) It was found that the risk of E-cadherin hypermethylation was 1.347-fold, while risk of p15 hypermethylation was 1.543-fold and p16 was 1.2-fold among patients with ovarian cancer than that among patients with benign ovarian lesions.
--- ABSTRACT ---
PMID:23572389 DOI:10.1177/0748233713484657
2015 Toxicology and industrial health
* Hypermethylation of P15, P16, and E-cadherin genes in ovarian cancer.
- Both p16 and p15 proteins are inhibitors of cyclin-dependent kinases that prevent the cell going through the G1/S phase transaction. E-cadherin is a transmembrane glycoprotein that mediates calcium-dependent interactions between adjacent epithelial cells. Two groups of patients were selected: the first group suffered from epithelial serous ovarian tumors and the second group suffered from benign ovarian lesions; ovarian tissue samples from all the subjects (benign and malignant) were subjected to methylation-specific polymerase chain reaction for methylated and unmethylated alleles of the genes (E-cadherin, p15, and p16). Results obtained showed that aberrant methylation of p15 and p16 genes were detected in 64.29 and 50% of ovarian cancer patients, while E-cadherin hypermethylation was detected in 78.57% of ovarian cancer patients. Methylation of E-cadherin was significantly correlated with different stage of disease (p < 0.05). It was found that the risk of E-cadherin hypermethylation was 1.347-fold, while risk of p15 hypermethylation was 1.543-fold and p16 was 1.2-fold among patients with ovarian cancer than that among patients with benign ovarian lesions. In conclusion, Dysfunction of the cell cycle and/or the cell-cell adhesion molecule plays a role in the pathogenesis of ovarian cancer and that the analysis of the methylation of p15 and E-cadherin genes can provide clinically important evidence on which to base the treatment.
--- ABSTRACT END ---
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(1)23 chronic (21)3 AD (41)2 CAD (61)2 critical
(2)13 a (22)3 AgP (42)2 CKD (62)2 diabetes,
(3)10 diabetes (23)3 CTD (43)2 CVD (63)2 early
(4)9 acute (24)3 an (44)2 DIC (64)2 equal
(5)8 severe (25)3 cardiovascular (45)2 LGV (65)2 hard-to-heal
(6)6 cancer (26)3 comorbid (46)2 MFS (66)2 higher
(7)6 congenital (27)3 end-stage (47)2 NE (67)2 ischemic
(8)5 RA (28)3 fibromyalgia (48)2 NSTE-ACS (68)2 lesions
(9)5 and (29)3 heart (49)2 SS (69)2 limited
(10)5 hypertension (30)3 known (50)2 SSc (70)2 moderate
(11)5 type (31)3 nonvalvular (51)2 ST-segment (71)2 no
(12)4 STEMI (32)3 osteoarthritis (52)2 VLUs (72)2 normal
(13)4 advanced (33)3 ovarian (53)2 VTE (73)2 pressure
(14)4 breast (34)3 poor (54)2 angina (74)2 prior
(15)4 dementia (35)3 schizophrenia (55)2 antiheparin/PF4 (75)2 refractory
(16)4 low (36)3 sickle (56)2 asthma (76)2 sarcoidosis
(17)4 sepsis (37)3 symptomatic (57)2 atrial (77)2 somatoform
(18)4 stable (38)3 the (58)2 central (78)2 stroke
(19)4 this (39)2 AHA (59)2 clinical (79)2 sudden
(20)4 venous (40)2 BD (60)2 coronary

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---