ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [no cache] 500 found
172) ANKRD18B methylation was more frequently observed in patients with poor differentiation (P < 0.05).
--- ABSTRACT ---
PMID:24249358 DOI:10.1002/mc.22101
2015 Molecular carcinogenesis
* Epigenetic regulation of ANKRD18B in lung cancer.
- The identification of the key genetic and epigenetic changes underlying lung carcinogenesis would aid effective early diagnosis and targeted therapies for lung cancer. In this study, we screened a novel hypermethylated gene ankyrin repeat domain 18B (ANKRD18B), to determine whether it is regulated by DNA methylation and clarify its biological and clinical implications in lung cancer. Methylation status and expression level were analyzed by methylation-specific PCR, bisulfite genomic sequencing, and quantitative reverse transcription-polymerase chain reaction (qRT-PCR). We detected ANKRD18B hypermethylation in 52 of 98 (53.1%) primary lung cancer tissues and in nine of 10 (90%) cell lines, whereas no methylation was seen in 10 normal lung tissue samples. ANKRD18B methylation was more frequently observed in patients with poor differentiation (P < 0.05). Notably, 62 pairs of samples from patients whose tumor tissue showed hypermethylation of ANKRD18B exhibited the same aberrant methylation in 72.7% and 69.7% of their corresponding plasma and sputum samples, respectively; whereas no hypermethylation of ANKRD18B was detected in the sputum and plasma from patients whose tumor sample lacked this alteration. In addition, ANKRD18B mRNA expression was significantly decreased or silenced in lung cancer tissues and cell lines associated with hypermethylation of the ANKRD18B region. Demethylation agent 5-aza-2'-deoxycytidine significantly increased ANKRD18B mRNA expression in lung cancer cell lines. Furthermore, overexpression of ANKRD18B suppressed lung cancer cell growth. These results suggest that the expression of ANKRD18B is regulated by CpG island hypermethylation in lung cancer. Our findings confirm the importance of the identification of new markers of epigenetic dysregulation in cancer.
--- ABSTRACT END ---
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(1)23 chronic (21)3 AD (41)2 CAD (61)2 critical
(2)13 a (22)3 AgP (42)2 CKD (62)2 diabetes,
(3)10 diabetes (23)3 CTD (43)2 CVD (63)2 early
(4)9 acute (24)3 an (44)2 DIC (64)2 equal
(5)8 severe (25)3 cardiovascular (45)2 LGV (65)2 hard-to-heal
(6)6 cancer (26)3 comorbid (46)2 MFS (66)2 higher
(7)6 congenital (27)3 end-stage (47)2 NE (67)2 ischemic
(8)5 RA (28)3 fibromyalgia (48)2 NSTE-ACS (68)2 lesions
(9)5 and (29)3 heart (49)2 SS (69)2 limited
(10)5 hypertension (30)3 known (50)2 SSc (70)2 moderate
(11)5 type (31)3 nonvalvular (51)2 ST-segment (71)2 no
(12)4 STEMI (32)3 osteoarthritis (52)2 VLUs (72)2 normal
(13)4 advanced (33)3 ovarian (53)2 VTE (73)2 pressure
(14)4 breast (34)3 poor (54)2 angina (74)2 prior
(15)4 dementia (35)3 schizophrenia (55)2 antiheparin/PF4 (75)2 refractory
(16)4 low (36)3 sickle (56)2 asthma (76)2 sarcoidosis
(17)4 sepsis (37)3 symptomatic (57)2 atrial (77)2 somatoform
(18)4 stable (38)3 the (58)2 central (78)2 stroke
(19)4 this (39)2 AHA (59)2 clinical (79)2 sudden
(20)4 venous (40)2 BD (60)2 coronary

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---