ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]
249) The RAMPART trial (NCT03288532) brings together both of these processes in an attempt to improve outcomes for patients with locally advanced renal cell carcinoma (RCC), where no globally acceptable adjuvant strategy after nephrectomy currently exist.
--- ABSTRACT ---
PMID:34538401 DOI:10.1016/j.cct.2021.106481
2021 Contemporary clinical trials
* RAMPART: A model for a regulatory-ready academic-led phase III trial in the adjuvant renal cell carcinoma setting.
- The development of therapeutics in oncology is a highly active research area for the pharmaceutical and biotechnology industries, but also has a strong academic base. Many new agents have been developed in recent years, most with specific biological targets. This has mandated the need to look at different ways to streamline the evaluation of new agents. One solution has been the development of adaptive trial designs that allow the evaluation of multiple agents, concentrating on the most promising agents while screening out those which are unlikely to benefit patients. Another way forward has been the growth of partnerships between academia and industry with the shared goal of designing and conducting high quality clinical trials which answer important clinical questions as efficiently as possible. The RAMPART trial (NCT03288532) brings together both of these processes in an attempt to improve outcomes for patients with locally advanced renal cell carcinoma (RCC), where no globally acceptable adjuvant strategy after nephrectomy currently exist. RAMPART is led by the MRC CTU at University College London (UCL), in collaboration with other international academic groups and industry. We aim to facilitate the use of data from RAMPART, (dependent on outcomes), for a future regulatory submission that will extend the license of the agents being investigated. We share our experience in order to lay the foundations for an effective trial design and conduct framework and to guide others who may be considering similar collaborations. Trial Registration: ISRCTN #: ISRCTN53348826, NCT #: NCT03288532, EUDRACT #: 2017-002329-39. CTA #: 20363/0380/001-0001. MREC #: 17/LO/1875. ClinicalTrials.gov Identifier: NCT03288532 RAMPART grant number: MC_UU_12023/25. . RAMPART Protocol version 5.0.
--- ABSTRACT END ---
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(1)14 a (26)3 PAH (51)2 IgAn (76)2 neurological
(2)14 severe (27)3 PTB (52)2 MIS-C (77)2 no
(3)12 COVID-19 (28)3 SB (53)2 MS, (78)2 or
(4)10 cancer (29)3 and (54)2 PH, (79)2 pancreatic
(5)10 chronic (30)3 autonomic (55)2 TSC (80)2 pre-existing
(6)8 diabetes (31)3 clinical (56)2 UWS (81)2 prolonged
(7)7 acute (32)3 dysphagia (57)2 accuracies (82)2 psoriasis
(8)6 relapsed (33)3 epilepsy (58)2 ankylosing (83)2 pulmonary
(9)5 AN (34)3 idiopathic (59)2 any (84)2 resected
(10)5 MDD (35)3 inflammatory (60)2 cerebellar (85)2 respiratory
(11)5 T2DM (36)3 newly (61)2 community-based (86)2 rheumatoid
(12)5 advanced (37)3 recurrent (62)2 comorbidities (87)2 schizophrenia
(13)5 lipoedema (38)3 uncontrolled (63)2 drug-resistant (88)2 shared
(14)4 AD (39)2 16p11.2 (64)2 heart (89)2 special
(15)4 IBD (40)2 ALL (65)2 hemorrhagic (90)2 spondyloarthritis
(16)4 breast (41)2 ALS (66)2 high (91)2 stage
(17)4 chorea (42)2 AML (67)2 high-risk (92)2 suspected
(18)4 critical (43)2 ASD (68)2 known (93)2 symptomatic
(19)4 low (44)2 BM (69)2 locally (94)2 the
(20)3 ARDS (45)2 CHB (70)2 lung (95)2 these
(21)3 CKD (46)2 COVID-19, (71)2 mIDH1 (96)2 treatment-resistant
(22)3 CLL (47)2 CRC (72)2 major (97)2 tuberculosis
(23)3 HGSOC (48)2 CVDRF (73)2 metastatic
(24)3 ILD (49)2 HIV (74)2 mild
(25)3 MD (50)2 IIM (75)2 neurologic

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---