ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]
29) Patients with COVID-19 (n = 172) had markedly elevated levels of calprotectin in their blood.
--- ABSTRACT ---
PMID:32869342 DOI:10.1002/JLB.3COVCRA0720-359R
2021 Journal of leukocyte biology
* Neutrophil calprotectin identifies severe pulmonary disease in COVID-19.
- Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels of blood neutrophils associate with worsening oxygenation in COVID-19, it is unknown whether neutrophils are drivers of the thrombo-inflammatory storm or simple bystanders. To better understand the potential role of neutrophils in COVID-19, we measured levels of the neutrophil activation marker S100A8/A9 (calprotectin) in hospitalized patients and determined its relationship to severity of illness and respiratory status. Patients with COVID-19 (n = 172) had markedly elevated levels of calprotectin in their blood. Calprotectin tracked with other acute phase reactants including C-reactive protein, ferritin, lactate dehydrogenase, and absolute neutrophil count, but was superior in identifying patients requiring mechanical ventilation. In longitudinal samples, calprotectin rose as oxygenation worsened. When tested on day 1 or 2 of hospitalization (n = 94 patients), calprotectin levels were significantly higher in patients who progressed to severe COVID-19 requiring mechanical ventilation (8039 ± 7031 ng/ml, n = 32) as compared to those who remained free of intubation (3365 ± 3146, P < 0.0001). In summary, serum calprotectin levels track closely with current and future COVID-19 severity, implicating neutrophils as potential perpetuators of inflammation and respiratory compromise in COVID-19.
--- ABSTRACT END ---
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[frequency of next (right) word to patients with]
(1)14 a (26)3 PAH (51)2 IgAn (76)2 neurological
(2)14 severe (27)3 PTB (52)2 MIS-C (77)2 no
(3)12 COVID-19 (28)3 SB (53)2 MS, (78)2 or
(4)10 cancer (29)3 and (54)2 PH, (79)2 pancreatic
(5)10 chronic (30)3 autonomic (55)2 TSC (80)2 pre-existing
(6)8 diabetes (31)3 clinical (56)2 UWS (81)2 prolonged
(7)7 acute (32)3 dysphagia (57)2 accuracies (82)2 psoriasis
(8)6 relapsed (33)3 epilepsy (58)2 ankylosing (83)2 pulmonary
(9)5 AN (34)3 idiopathic (59)2 any (84)2 resected
(10)5 MDD (35)3 inflammatory (60)2 cerebellar (85)2 respiratory
(11)5 T2DM (36)3 newly (61)2 community-based (86)2 rheumatoid
(12)5 advanced (37)3 recurrent (62)2 comorbidities (87)2 schizophrenia
(13)5 lipoedema (38)3 uncontrolled (63)2 drug-resistant (88)2 shared
(14)4 AD (39)2 16p11.2 (64)2 heart (89)2 special
(15)4 IBD (40)2 ALL (65)2 hemorrhagic (90)2 spondyloarthritis
(16)4 breast (41)2 ALS (66)2 high (91)2 stage
(17)4 chorea (42)2 AML (67)2 high-risk (92)2 suspected
(18)4 critical (43)2 ASD (68)2 known (93)2 symptomatic
(19)4 low (44)2 BM (69)2 locally (94)2 the
(20)3 ARDS (45)2 CHB (70)2 lung (95)2 these
(21)3 CKD (46)2 COVID-19, (71)2 mIDH1 (96)2 treatment-resistant
(22)3 CLL (47)2 CRC (72)2 major (97)2 tuberculosis
(23)3 HGSOC (48)2 CVDRF (73)2 metastatic
(24)3 ILD (49)2 HIV (74)2 mild
(25)3 MD (50)2 IIM (75)2 neurologic

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---