ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for patients with out of >500 occurrences
404916 occurrences (No.41 in the rank) during 5 years in the PubMed. [cache]
93) This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation.
--- ABSTRACT ---
PMID:24174332 DOI:10.1007/s11427-013-4568-z
2015 Science China. Life sciences
* Learning from berberine: Treating chronic diseases through multiple targets.
- Although advances have been made, chemotherapy for chronic, multifactorial diseases such as cancers, Alzheimer's disease, cardiovascular diseases and diabetes is far from satisfactory. Agents with different mechanisms of action are required. The botanic compound berberine (BBR) has been used as an over-the-counter antibacterial for diarrhea in China for many decades. Recent clinical studies have shown that BBR may be therapeutic in various types of chronic diseases. This review addresses BBR's molecular mechanisms of action and clinical efficacy and safety in patients with type 2 diabetes, hyperlipidemia, heart diseases, cancers and inflammation. One of the advantages of BBR is its multiple-target effects in each of these diseases. The therapeutic efficacy of BBR may reflect a synergistic regulation of these targets, resulting in a comprehensive effect against these various chronic disorders. The safety of BBR may be due to its harmonious distribution into those targets. Although the single-target concept is still the principle for drug discovery and research, this review emphasizes the concept of a multiple target strategy, which may be an important approach toward the successful treatment of multifactorial chronic diseases.
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[frequency of next (right) word to patients with]
(1)23 chronic (21)3 AD (41)2 CAD (61)2 critical
(2)13 a (22)3 AgP (42)2 CKD (62)2 diabetes,
(3)10 diabetes (23)3 CTD (43)2 CVD (63)2 early
(4)9 acute (24)3 an (44)2 DIC (64)2 equal
(5)8 severe (25)3 cardiovascular (45)2 LGV (65)2 hard-to-heal
(6)6 cancer (26)3 comorbid (46)2 MFS (66)2 higher
(7)6 congenital (27)3 end-stage (47)2 NE (67)2 ischemic
(8)5 RA (28)3 fibromyalgia (48)2 NSTE-ACS (68)2 lesions
(9)5 and (29)3 heart (49)2 SS (69)2 limited
(10)5 hypertension (30)3 known (50)2 SSc (70)2 moderate
(11)5 type (31)3 nonvalvular (51)2 ST-segment (71)2 no
(12)4 STEMI (32)3 osteoarthritis (52)2 VLUs (72)2 normal
(13)4 advanced (33)3 ovarian (53)2 VTE (73)2 pressure
(14)4 breast (34)3 poor (54)2 angina (74)2 prior
(15)4 dementia (35)3 schizophrenia (55)2 antiheparin/PF4 (75)2 refractory
(16)4 low (36)3 sickle (56)2 asthma (76)2 sarcoidosis
(17)4 sepsis (37)3 symptomatic (57)2 atrial (77)2 somatoform
(18)4 stable (38)3 the (58)2 central (78)2 stroke
(19)4 this (39)2 AHA (59)2 clinical (79)2 sudden
(20)4 venous (40)2 BD (60)2 coronary

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--- WordNet output for patients --- Overview of noun patient The noun patient has 2 senses (first 1 from tagged texts) 1. (73) patient -- (a person who requires medical care; "the number of emergency patients has grown rapidly") 2. affected role, patient role, patient -- (the semantic role of an entity that is not the agent but is directly involved in or affected by the happening denoted by the verb in the clause) --- WordNet end ---