ELIZA

return kwic search for performed out of >500 occurrences
272110 occurrences (No.94 in the rank) during 5 years in the PubMed. [no cache] 500 found

221) This study performed on sheep explants shows that 1 mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition.

--- ABSTRACT ---

PMID:24168233 DOI:10.3109/03639045.2013.850704

2015 Drug development and industrial pharmacy

* In vitro evaluation of S-(+)-ibuprofen as drug candidate for intra-articular drug delivery system.

- Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13 days with LPS in combination with S-(+)-ibuprofen at 50 µM and 1 mM. S-(+)-ibuprofen (50 µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1 mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p = 0.0072), proteoglycans degradation by 35% (p = 0.0114) and expression of serum amyloid protein - the main protein induced upon LPS challenge - by 44% (p < 0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1 mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50 µM in all treatment groups and reduction of cartilage degradation observed at 1 mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to performed]

(1)60 in	(10)15 for	(19)3 based	(28)2 equally
(2)58 null	(11)13 at	(20)3 of	(29)2 normally
(3)45 to	(12)6 as	(21)3 this	(30)2 procedures
(4)35 using	(13)5 the	(22)2 3	(31)2 successfully
(5)33 on	(14)5 under	(23)2 6	(32)2 three
(6)30 with	(15)5 via	(24)2 better	(33)2 through
(7)23 by	(16)4 an	(25)2 both	(34)2 twice
(8)22 a	(17)4 before	(26)2 but
(9)16 and	(18)3 after	(27)2 daily

add keyword

--- WordNet output for performed --- Overview of verb perform The verb perform has 4 senses (first 4 from tagged texts) 1. (25) perform, execute, do -- (carry out or perform an action; "John did the painting, the weeding, and he cleaned out the gutters"; "the skater executed a triple pirouette"; "she did a little dance") 2. (19) perform -- (perform a function; "Who will perform the wedding?") 3. (19) perform -- (give a performance (of something); "Horowitz is performing at Carnegie Hall tonight"; "We performed a popular Gilbert and Sullivan opera") 4. (2) do, perform -- (get (something) done; "I did my job") --- WordNet end ---