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return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found

272) Taken together, our results demonstrate BIO's potential utility as a proliferative agent for cell transplantation and tissue regeneration.

--- ABSTRACT ---

PMID:23554411 DOI:10.1002/term.1736

2015 Journal of tissue engineering and regenerative medicine

* Agonism of Wnt-β-catenin signalling promotes mesenchymal stem cell (MSC) expansion.

- Promoting mesenchymal stem cell (MSC) proliferation has numerous applications in stem cell therapies, particularly in the area of regenerative medicine. In order for cell-based regenerative approaches to be realized, MSC proliferation must be achieved in a controlled manner without compromising stem cell differentiation capacities. Here we demonstrate that 6-bromoindirubin-3'-oxime (BIO) increases MSC β-catenin activity 106-fold and stem cell-associated gene expression ~33-fold, respectively, over untreated controls. Subsequently, BIO treatment increases MSC populations 1.8-fold in typical 2D culture conditions, as well as 1.3-fold when encapsulated within hydrogels compared to untreated cells. Furthermore, we demonstrate that BIO treatment does not reduce MSC multipotency where MSCs maintain their ability to differentiate into osteoblasts, chondrocytes and adipocytes using standard conditions. Taken together, our results demonstrate BIO's potential utility as a proliferative agent for cell transplantation and tissue regeneration.

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(1)67 of	(15)4 effects	(29)2 by	(43)2 mediator
(2)39 to	(16)4 guardian	(30)2 clinical	(44)2 new
(3)35 for	(17)4 mechanism	(31)2 confounders	(45)2 pathways
(4)14 null	(18)4 mechanisms	(32)2 confounders,	(46)2 perils
(5)13 in	(19)3 adverse	(33)2 directions	(47)2 preventive
(6)10 as	(20)3 applications	(34)2 drug	(48)2 risks
(7)10 risk	(21)3 association	(35)2 factors	(49)2 than
(8)8 role	(22)3 cytotoxicity	(36)2 future	(50)2 therapy
(9)8 use	(23)3 genotoxic	(37)2 harm	(51)2 toxicity
(10)7 and	(24)3 influence	(38)2 hazards	(52)2 vaccine
(11)7 therapeutic	(25)3 pitfalls	(39)2 impact	(53)2 was
(12)6 benefits	(26)3 utility	(40)2 is
(13)5 health	(27)3 value	(41)2 issues
(14)5 predictors	(28)2 biomarker	(42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---