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return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found

273) Further investigation of these resistance mechanisms and the potential utility of Aurora kinase inhibitors in multi-agent protocols is warranted.

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PMID:23410058 DOI:10.1111/vco.12018

2015 Veterinary and comparative oncology

* Canine osteosarcoma cells exhibit resistance to aurora kinase inhibitors.

- We evaluated the effect of Aurora kinase inhibitors AZD1152 and VX680 on canine osteosarcoma cells. Cytotoxicity was seen in all four cell lines; however, half-maximal inhibitory concentrations were significantly higher than in human leukaemia and canine lymphoma cells. AZD1152 reduced Aurora kinase B phosphorylation, indicating resistance was not because of failure of target recognition. Efflux mediated by ABCB1 and ABCG2 transporters is one known mechanism of resistance against these drugs and verapamil enhanced AZD1152-induced apoptosis; however, these transporters were only expressed by a small percentage of cells in each line and the effects of verapamil were modest, suggesting other mechanisms contribute to resistance. Our results indicate that canine osteosarcoma cells are resistant to Aurora kinase inhibitors and suggest that these compounds are unlikely to be useful as single agents for this disease. Further investigation of these resistance mechanisms and the potential utility of Aurora kinase inhibitors in multi-agent protocols is warranted.

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(1)67 of	(15)4 effects	(29)2 by	(43)2 mediator
(2)39 to	(16)4 guardian	(30)2 clinical	(44)2 new
(3)35 for	(17)4 mechanism	(31)2 confounders	(45)2 pathways
(4)14 null	(18)4 mechanisms	(32)2 confounders,	(46)2 perils
(5)13 in	(19)3 adverse	(33)2 directions	(47)2 preventive
(6)10 as	(20)3 applications	(34)2 drug	(48)2 risks
(7)10 risk	(21)3 association	(35)2 factors	(49)2 than
(8)8 role	(22)3 cytotoxicity	(36)2 future	(50)2 therapy
(9)8 use	(23)3 genotoxic	(37)2 harm	(51)2 toxicity
(10)7 and	(24)3 influence	(38)2 hazards	(52)2 vaccine
(11)7 therapeutic	(25)3 pitfalls	(39)2 impact	(53)2 was
(12)6 benefits	(26)3 utility	(40)2 is
(13)5 health	(27)3 value	(41)2 issues
(14)5 predictors	(28)2 biomarker	(42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---