ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for potential out of >500 occurrences
545945 occurrences (No.21 in the rank) during 5 years in the PubMed. [no cache] 500 found
4) However, understanding the PPN's role in PD and assessing the potential of DBS are hampered by the lack of a suitable model of PPN degeneration.
--- ABSTRACT ---
PMID:24292256 DOI:10.1007/s00429-013-0669-5
2015 Brain structure & function
* An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease.
- A rostral brainstem structure, the pedunculopontine nucleus (PPN), is severely affected by Parkinson's disease (PD) pathology and is regarded a promising target for therapeutic deep-brain stimulation (DBS). However, understanding the PPN's role in PD and assessing the potential of DBS are hampered by the lack of a suitable model of PPN degeneration. Rats were rendered Parkinsonian through a unilateral substantia nigra pars compacta (SNpc) stereotaxic injection of the proteasome inhibitor Lactacystin, to investigate whether the lesion's pathological effects spread to impact the integrity of PPN cholinergic neurons which are affected in PD. At 5 weeks post-surgery, stereological analysis revealed that the lesion caused a 48 % loss of dopaminergic SNpc neurons and a 61 % loss of PPN cholinergic neurons, accompanied by substantial somatic hypotrophy in the remaining cholinergic neurons. Magnetic resonance imaging revealed T2 signal hyper-/hypointensity in the PPN of the injected hemisphere, respectively at weeks 3 and 5 post-lesion. Moreover, isolated PPN cholinergic neurons revealed no significant alterations in key autophagy mRNA levels, suggesting that autophagy-related mechanisms fail to protect the PPN against Lactacystin-induced cellular changes. Hence, the current results suggest that the Lactacystin PD model offers a suitable model for investigating the role of the PPN in PD.
--- ABSTRACT END ---
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[frequency of next (right) word to potential]
(1)67 of (15)4 effects (29)2 by (43)2 mediator
(2)39 to (16)4 guardian (30)2 clinical (44)2 new
(3)35 for (17)4 mechanism (31)2 confounders (45)2 pathways
(4)14 *null* (18)4 mechanisms (32)2 confounders, (46)2 perils
(5)13 in (19)3 adverse (33)2 directions (47)2 preventive
(6)10 as (20)3 applications (34)2 drug (48)2 risks
(7)10 risk (21)3 association (35)2 factors (49)2 than
(8)8 role (22)3 cytotoxicity (36)2 future (50)2 therapy
(9)8 use (23)3 genotoxic (37)2 harm (51)2 toxicity
(10)7 and (24)3 influence (38)2 hazards (52)2 vaccine
(11)7 therapeutic (25)3 pitfalls (39)2 impact (53)2 was
(12)6 benefits (26)3 utility (40)2 is
(13)5 health (27)3 value (41)2 issues
(14)5 predictors (28)2 biomarker (42)2 maximum

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--- WordNet output for potential --- =>可能性のある, 可能な, 潜在力のある, 位置の, 電位の, 潜在的な, ポテンシャル, 可能性, 電位 Overview of noun potential The noun potential has 2 senses (first 1 from tagged texts) 1. (10) potential, potentiality, potency -- (the inherent capacity for coming into being) 2. electric potential, potential, potential difference, potential drop, voltage -- (the difference in electrical charge between two points in a circuit expressed in volts) Overview of adj potential The adj potential has 2 senses (first 2 from tagged texts) 1. (7) potential, possible -- (existing in possibility; "a potential problem"; "possible uses of nuclear power") 2. (6) likely, potential -- (expected to become or be; in prospect; "potential clients") --- WordNet end ---