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325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [no cache] 500 found

182) These results provide evidence for a role of H-ras oncogene in the metabolic reprogramming of MCF10A cells during early mammary carcinogenesis.

--- ABSTRACT ---

PMID:24000146 DOI:10.1002/mc.22079

2015 Molecular carcinogenesis

* Altered glucose metabolism in Harvey-ras transformed MCF10A cells.

- Metabolic reprogramming that alters the utilization of glucose including the "Warburg effect" is critical in the development of a tumorigenic phenotype. However, the effects of the Harvey-ras (H-ras) oncogene on cellular energy metabolism during mammary carcinogenesis are not known. The purpose of this study was to determine the effect of H-ras transformation on glucose metabolism using the untransformed MCF10A and H-ras oncogene transfected (MCF10A-ras) human breast epithelial cells, a model for early breast cancer progression. We measured the metabolite fluxes at the cell membrane by a selective micro-biosensor, [(13)C6 ]glucose flux by (13)C-mass isotopomer distribution analysis of media metabolites, intracellular metabolite levels by NMR, and gene expression of glucose metabolism enzymes by quantitative PCR. Results from these studies indicated that MCF10A-ras cells exhibited enhanced glycolytic activity and lactate production, decreased glucose flux through the tricarboxylic acid (TCA) cycle, as well as an increase in the utilization of glucose in the pentose phosphate pathway (PPP). These results provide evidence for a role of H-ras oncogene in the metabolic reprogramming of MCF10A cells during early mammary carcinogenesis.

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[frequency of next (right) word to provide]

(1)109 a	(12)6 insight	(23)3 care	(34)2 effective
(2)39 an	(13)6 recommendations	(24)3 direct	(35)2 first
(3)32 the	(14)5 reliable	(25)3 guidance	(36)2 for
(4)25 evidence	(15)5 them	(26)3 novel	(37)2 good
(5)14 useful	(16)4 information	(27)3 preliminary	(38)2 greater
(6)13 new	(17)4 insights	(28)2 accurate	(39)2 methodological
(7)8 more	(18)4 such	(29)2 additional	(40)2 one
(8)7 rather	(19)4 us	(30)2 analytical	(41)2 some
(9)7 support	(20)4 valuable	(31)2 answers	(42)2 sufficient
(10)6 further	(21)3 adequate	(32)2 basic	(43)2 to
(11)6 important	(22)3 better	(33)2 clinically

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--- WordNet output for provide --- =>供給する, 与える, 規定する, 条件とする, 準備する, 用意する, 扶養する, 援助する Overview of verb provide The verb provide has 7 senses (first 4 from tagged texts) 1. (270) supply, provide, render, furnish -- (give something useful or necessary to; "We provided the room with an electrical heater") 2. (25) provide, supply, ply, cater -- (give what is desired or needed, especially support, food or sustenance; "The hostess provided lunch for all the guests") 3. (14) provide -- (determine (what is to happen in certain contingencies), especially by including a proviso condition or stipulation; "The will provides that each child should receive half of the money"; "The Constitution provides for the right to free speech") 4. (2) put up, provide, offer -- (mount or put up; "put up a good fight"; "offer resistance") 5. leave, allow for, allow, provide -- (make a possibility or provide opportunity for; permit to be attainable or cause to remain; "This leaves no room for improvement"; "The evidence allows only one conclusion"; "allow for mistakes"; "leave lots of time for the trip"; "This procedure provides for lots of leeway") 6. provide, bring home the bacon -- (supply means of subsistence; earn a living; "He provides for his large family by working three jobs"; "Women nowadays not only take care of the household but also bring home the bacon") 7. provide -- (take measures in preparation for; "provide for the proper care of the passengers on the cruise ship") --- WordNet end ---