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325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]
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325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]
| 194) We used sequence conservation and mutational analyses to provide evidence of a putative binding interface for GN1. |
| PMID:33989636 DOI:10.1016/j.jbc.2021.100772 |
| 2021 The Journal of biological chemistry |
| * Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1. |
| - Tripartite motif (TRIM)7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1 (GN1), the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence indicates that TRIM7 plays an important role in cancer development, viral pathogenesis, and atherosclerosis and, thus, represents a potential therapeutic target. TRIM family proteins share a multidomain architecture with a conserved N-terminal TRIM and a variable C-terminal domain. Human TRIM7 contains the canonical TRIM motif and a B30.2 domain at the C terminus. To contribute to the understanding of the mechanism of action of TRIM7, we solved the X-ray crystal structure of its B30.2 domain (TRIM7B30.2) in two crystal forms at resolutions of 1.6 Å and 1.8 Å. TRIM7B30.2 exhibits the typical B30.2 domain fold, consisting of two antiparallel β-sheets of seven and six strands, arranged as a distorted β-sandwich. Furthermore, two long loops partially cover the concave face of the β-sandwich defined by the β-sheet of six strands, thus forming a positively charged cavity. We used sequence conservation and mutational analyses to provide evidence of a putative binding interface for GN1. These studies showed that Leu423, Ser499, and Cys501 of TRIM7B30.2 and the C-terminal 33 amino acids of GN1 are critical for this binding interaction. Molecular dynamics simulations also revealed that hydrogen bond and hydrophobic interactions play a major role in the stability of a modeled TRIM7B30.2-GN1 C-terminal peptide complex. These data provide useful information that could be used to target this interaction for the development of potential therapeutic agents. |
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(12)7 insight |
(23)3 sufficient |
(34)2 patients |
| (2)63 an |
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(24)3 support |
(35)2 protection |
| (3)15 evidence |
(14)6 guidance |
(25)2 adequate |
(36)2 readers |
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(15)6 information |
(26)2 care |
(37)2 reasonable |
| (5)12 new |
(16)6 some |
(27)2 critical |
(38)2 reliable |
| (6)11 recommendations |
(17)5 novel |
(28)2 detailed |
(39)2 robust |
| (7)9 insights |
(18)4 better |
(29)2 direct |
(40)2 strong |
| (8)9 valuable |
(19)4 opportunities |
(30)2 greater |
(41)2 suggestions |
| (9)7 additional |
(20)4 useful |
(31)2 hypotheses |
(42)2 treatment |
| (10)7 further |
(21)3 practical |
(32)2 key |
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| (11)7 important |
(22)3 researchers |
(33)2 mechanistic |
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--- WordNet output for provide ---