kwic
provide
provide
right
off
ON
260
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for provide out of >500 occurrences
325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to provide]
325270 occurrences (No.61 in the rank) during 5 years in the PubMed. [cache]
| 260) Collectively, these findings provide additional evidence that IGF-1 is critical for cerebromicrovascular endothelial health and maintenance of normal NVC responses. |
| PMID:34383203 DOI:10.1007/s11357-021-00405-2 |
| 2021 GeroScience |
| * Endothelial deficiency of insulin-like growth factor-1 receptor (IGF1R) impairs neurovascular coupling responses in mice, mimicking aspects of the brain aging phenotype. |
| - Age-related impairment of neurovascular coupling (NVC; or "functional hyperemia") compromises moment-to-moment adjustment of regional cerebral blood flow to increased neuronal activity and thereby contributes to the pathogenesis of vascular cognitive impairment (VCI). Previous studies established a causal link among age-related decline in circulating levels of insulin-like growth factor-1 (IGF-1), neurovascular dysfunction and cognitive impairment. Endothelium-mediated microvascular dilation plays a central role in NVC responses. To determine the functional consequences of impaired IGF-1 input to cerebromicrovascular endothelial cells, endothelium-mediated NVC responses were studied in a novel mouse model of accelerated neurovascular aging: mice with endothelium-specific knockout of IGF1R (VE-Cadherin-CreERT2/Igf1rf/f). Increases in cerebral blood flow in the somatosensory whisker barrel cortex (assessed using laser speckle contrast imaging through a cranial window) in response to contralateral whisker stimulation were significantly attenuated in VE-Cadherin-CreERT2/Igf1rf/f mice as compared to control mice. In VE-Cadherin-CreERT2/Igf1rf/f mice, the effects of the NO synthase inhibitor L-NAME were significantly decreased, suggesting that endothelium-specific disruption of IGF1R signaling impairs the endothelial NO-dependent component of NVC responses. Collectively, these findings provide additional evidence that IGF-1 is critical for cerebromicrovascular endothelial health and maintenance of normal NVC responses. |
[
right
kwic]
(1)125  a |
(12)7 insight |
(23)3 sufficient |
(34)2 patients |
| (2)63 an |
(13)7 more |
(24)3 support |
(35)2 protection |
| (3)15 evidence |
(14)6 guidance |
(25)2 adequate |
(36)2 readers |
| (4)13 the |
(15)6 information |
(26)2 care |
(37)2 reasonable |
| (5)12 new |
(16)6 some |
(27)2 critical |
(38)2 reliable |
| (6)11 recommendations |
(17)5 novel |
(28)2 detailed |
(39)2 robust |
| (7)9 insights |
(18)4 better |
(29)2 direct |
(40)2 strong |
| (8)9 valuable |
(19)4 opportunities |
(30)2 greater |
(41)2 suggestions |
| (9)7 additional |
(20)4 useful |
(31)2 hypotheses |
(42)2 treatment |
| (10)7 further |
(21)3 practical |
(32)2 key |
|
| (11)7 important |
(22)3 researchers |
(33)2 mechanistic |
add keyword
--- WordNet output for provide ---