* Comparative studies for ciprofloxacin hydrochloride pre-formed gels and thermally triggered (in situ) gels: in vitro and in vivo appraisal using a bacterial keratitis model in rabbits.
- This article reports on comparative in vitro characterization and in vivo evaluation of pre-formed cellulose-based gels, methylcellulose (MC) and carboxymethylcellulose sodium (CMC) and in situ gel-forming Pluronic F127 (PL) for ocular delivery of ciprofloxacin hydrochloride (Cipro) by using a bacterial keratitis model and histological corneal examination. Drug-polymer interactions were studied employing thermal analysis. Further, different concentrations (1-3% w/w or 10-30% w/w) of gels depending on the nature of the polymer used were prepared, characterized for clarity, pH, rheology and in vitro release. Selected gel formulations were evaluated for ocular delivery to Staphylococcus aureus-infected rabbit corneas; and ocular toxicity through histological examination of the cornea. The results demonstrated no Cipro-polymers physicochemical interactions and pseudoplastic flow for all gels used at 35 °C. Both polymer concentrations and drug solubility in the gels are dominantly the rate-determining factors for in vitro drug release. The corneal healing rate for all gel-based formulations was significantly faster (p < 0.05) than that for Cipro solution-treated rabbits. PL-based gel induced significant swelling/edema of the corneal stroma, compared with MC- and CMC-based gels. In conclusion, cellulose-based polymers have superior ocular tolerability/dramatically less irritant; and superior efficacy with more convenient administration compared with PL and Cipro solution, respectively.
=>価格を評定する, 割合, 率, 歩合, 料金, 値段, 相場, 速度, 度合, 人を〜を思う, みなす, 価値がある,
人を〜とみなす, 科金, 評価する
Overview of noun rate
The noun rate has 4 senses (first 3 from tagged texts)
1. (68) rate -- (a magnitude or frequency relative to a time unit; "they traveled at a rate of 55
miles per hour"; "the rate of change was faster than expected")
2. (39) rate, charge per unit -- (amount of a charge or payment relative to some basis; "a 10-minute
phone call at that rate would cost $5")
3. (1) pace, rate -- (the relative speed of progress or change; "he lived at a fast pace"; "he works
at a great rate"; "the pace of events accelerated")
4. rate -- (a quantity or amount or measure considered as a proportion of another quantity or amount
or measure; "the literacy rate"; "the retention rate"; "the dropout rate")
Overview of verb rate
The verb rate has 3 senses (first 3 from tagged texts)
1. (9) rate, rank, range, order, grade, place -- (assign a rank or rating to; "how would you rank
these students?"; "The restaurant is rated highly in the food guide")
2. (2) rate -- (be worthy of or have a certain rating; "This bond rates highly")
3. (1) rate, value -- (estimate the value of; "How would you rate his chances to become President?";
"Gold was rated highly among the Romans")
--- WordNet end ---