ELIZA

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286534 occurrences (No.87 in the rank) during 5 years in the PubMed. [cache]

405) Long-term safety and efficacy of eltrombopag in adults with persitent/chronic primary immune thrombocytopenia (ITP) evaluated in EXTEND study, showed a high response rate (80%) but, in the clinical safety study, it was observed that 6% of the patients presented venous and arterial thrombotic events.

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PMID:33714615 DOI:10.1016/j.thromres.2021.02.021

2021 Thrombosis research

* Massive intrasplenic arterial thrombosis in a patient with chronic ITP during the development of an Evans syndrome.

- Long-term safety and efficacy of eltrombopag in adults with persitent/chronic primary immune thrombocytopenia (ITP) evaluated in EXTEND study, showed a high response rate (80%) but, in the clinical safety study, it was observed that 6% of the patients presented venous and arterial thrombotic events. In addition, in the course of the disease, autoimmune hemolytic anemia (Evans syndrome, ES) may occur and could increase the risk of thrombosis. We report an interesting case of splenic rupture due to massive intrasplenic arterial thrombosis in the course of ES in a patient with chronic ITP treated with eltrombopag. The purpose of this case report is to highlight the potential increase in thrombotic risk that may involve the use of eltrombopag in hemolysis situations in patients with ITP.

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[frequency of next (right) word to rate]

(1)172 of	(10)5 that	(19)3 step	(28)2 increased
(2)40 and	(11)5 the	(20)2 (ESR),	(29)2 it
(3)32 was	(12)4 (HR),	(21)2 (RMR)	(30)2 lactate,
(4)31 null	(13)4 among	(22)2 after	(31)2 or
(5)24 in	(14)4 discrimination	(23)2 at	(32)2 respiratory
(6)8 variability	(15)4 is	(24)2 attributable	(33)2 to
(7)6 constants	(16)4 were	(25)2 between	(34)2 top
(8)6 for	(17)3 enzyme	(26)2 constant	(35)2 which
(9)5 (HR)	(18)3 on	(27)2 equations

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--- WordNet output for rate --- =>価格を評定する, 割合, 率, 歩合, 料金, 値段, 相場, 速度, 度合, 人を〜を思う, みなす, 価値がある, 人を〜とみなす, 科金, 評価する Overview of noun rate The noun rate has 4 senses (first 3 from tagged texts) 1. (68) rate -- (a magnitude or frequency relative to a time unit; "they traveled at a rate of 55 miles per hour"; "the rate of change was faster than expected") 2. (39) rate, charge per unit -- (amount of a charge or payment relative to some basis; "a 10-minute phone call at that rate would cost $5") 3. (1) pace, rate -- (the relative speed of progress or change; "he lived at a fast pace"; "he works at a great rate"; "the pace of events accelerated") 4. rate -- (a quantity or amount or measure considered as a proportion of another quantity or amount or measure; "the literacy rate"; "the retention rate"; "the dropout rate") Overview of verb rate The verb rate has 3 senses (first 3 from tagged texts) 1. (9) rate, rank, range, order, grade, place -- (assign a rank or rating to; "how would you rank these students?"; "The restaurant is rated highly in the food guide") 2. (2) rate -- (be worthy of or have a certain rating; "This bond rates highly") 3. (1) rate, value -- (estimate the value of; "How would you rate his chances to become President?"; "Gold was rated highly among the Romans") --- WordNet end ---