ELIZA

return kwic search for research out of >500 occurrences
280501 occurrences (No.89 in the rank) during 5 years in the PubMed. [cache]

22) Replication has been weak and led many to challenge the overall significance of GxE research.

--- ABSTRACT ---

PMID:34645846 DOI:10.1038/s41598-021-98684-4

2021 Scientific reports

* Genome-wide stress sensitivity moderates the stress-depression relationship in a nationally representative sample of adults.

- We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and depression is moderated by a polymorphism in the promoter region (5-HTTLPR) of the gene SLC6A4. Replication has been weak and led many to challenge the overall significance of GxE research. Here, we utilize data from Add Health, a large, nationally representative, and well-powered longitudinal study to re-examine the genetic determinants of stress sensitivity. We characterize environmental sensitivity using a genome-wide polygenic indicator rather than relying on one polymorphism in a single candidate gene. Our results provide support for the stress-diathesis perspective and validate the scientific contributions of the original paper.

--- ABSTRACT END ---

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[frequency of next (right) word to research]

(1)43 null	(16)5 literature	(31)3 papers	(46)2 needs
(2)40 in	(17)5 was	(32)3 published	(47)2 participants
(3)38 is	(18)4 as	(33)3 regarding	(48)2 project
(4)32 on	(19)4 findings	(34)3 settings	(49)2 question
(5)29 and	(20)4 into	(35)2 Network	(50)2 question,
(6)16 has	(21)4 methods	(36)2 aims	(51)2 questions:
(7)15 should	(22)4 that	(37)2 area	(52)2 reports
(8)10 studies	(23)4 we	(38)2 available	(53)2 requires
(9)9 to	(24)3 activity	(39)2 capacity	(54)2 supporting
(10)7 gaps	(25)3 agenda	(40)2 design,	(55)2 synthesis
(11)7 questions	(26)3 areas	(41)2 efforts	(56)2 team
(12)6 are	(27)3 design	(42)2 efforts,	(57)2 waste
(13)6 articles	(28)3 designs	(43)2 fields
(14)5 about	(29)3 evidence	(44)2 included
(15)5 conducted	(30)3 from	(45)2 indicates

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--- WordNet output for research --- =>調査する, 研究(する), 探求, 調査, 捜索, 研究する Overview of noun research The noun research has 2 senses (first 2 from tagged texts) 1. (46) research -- (systematic investigation to establish facts) 2. (6) inquiry, enquiry, research -- (a search for knowledge; "their pottery deserves more research than it has received") Overview of verb research The verb research has 2 senses (first 1 from tagged texts) 1. (1) research -- (attempt to find out in a systematically and scientific manner; "The student researched the history of that word") 2. research, search, explore -- (inquire into; "the students had to research the history of the Second World War for their history project"; "He searched for information on his relatives on the web"; "Scientists are exploring the nature of consciousness") --- WordNet end ---