ELIZA

return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [no cache] 500 found

165) OIS is often characterized by aberrant DNA replication and the associated DNA damage response.

--- ABSTRACT ---

PMID:24486217 DOI:10.1016/j.canlet.2014.01.017

2015 Cancer letters

* Nucleotide metabolism, oncogene-induced senescence and cancer.

- Senescence is defined as a stable cell growth arrest. Oncogene-induced senescence (OIS) occurs when an activated oncogene is expressed in a normal cell. OIS acts as a bona fide tumor suppressor mechanism by driving stable growth arrest of cancer progenitor cells harboring the initial oncogenic hit. OIS is often characterized by aberrant DNA replication and the associated DNA damage response. Nucleotides, in particular deoxyribonucleotide triphosphates (dNTPs), are necessary for both DNA replication and repair. Imbalanced dNTP pools play a role in a number of human diseases, including during the early stages of cancer development. This review will highlight what is currently known about the role of decreased nucleotide metabolism in OIS, how nucleotide metabolism leads to transformation and tumor progression, and how this pathway can be targeted as a cancer therapeutic by inducing senescence of cancer cells.

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[frequency of next (right) word to response]

(1)146 to	(14)4 proteins	(27)3 time	(40)2 following
(2)32 null	(15)4 rates	(28)3 times	(41)2 from
(3)31 and	(16)4 that	(29)3 which	(42)2 including
(4)22 of	(17)4 the	(30)2 (ABR)	(43)2 latency
(5)21 rate	(18)3 at	(31)2 (DDR)	(44)2 mediated
(6)14 was	(19)3 during	(32)2 (UPR)	(45)2 or
(7)13 in	(20)3 elements	(33)2 after	(46)2 rate)
(8)8 selection	(21)3 models	(34)2 are	(47)2 rates,
(9)7 surface	(22)3 options	(35)2 boundaries	(48)2 such
(10)6 data	(23)3 properties	(36)2 delays	(49)2 theory
(11)6 is	(24)3 strategies	(37)2 effects	(50)2 validity
(12)4 for	(25)3 style	(38)2 element	(51)2 were
(13)4 patterns	(26)3 suppression	(39)2 evaluation

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---