ELIZA

return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [cache]

412) In addition to playing a critical role in the stress response, SGs have emerged as critical mediators in human health.

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PMID:35004322 DOI:10.3389/fonc.2021.797549

2021 Frontiers in oncology

* Stress Granules in the Anti-Cancer Medications Mechanism of Action: A Systematic Scoping Review.

- Stress granule (SG) formation is a well-known cellular mechanism for minimizing stress-related damage and increasing cell survival. In addition to playing a critical role in the stress response, SGs have emerged as critical mediators in human health. It seems logical that SGs play a key role in cancer cell formation, development, and metastasis. Recent studies have shown that many SG components contribute to the anti-cancer medications' responses through tumor-associated signaling pathways and other mechanisms. SG proteins are known for their involvement in the translation process, control of mRNA stability, and capacity to function in both the cytoplasm and nucleus. The current systematic review aimed to include all research on the impact of SGs on the mechanism of action of anti-cancer medications and was conducted using a six-stage methodological framework and the PRISMA guideline. Prior to October 2021, a systematic search of seven databases for eligible articles was performed. Following the review of the publications, the collected data were subjected to quantitative and qualitative analysis. Notably, Bortezomib, Sorafenib, Oxaliplatin, 5-fluorouracil, Cisplatin, and Doxorubicin accounted for the majority of the medications examined in the studies. Overall, this systematic scoping review attempts to demonstrate and give a complete overview of the function of SGs in the mechanism of action of anti-cancer medications by evaluating all research.

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(1)170 to	(11)5 rates	(21)2 although	(31)2 profiles
(2)56 null	(12)5 with	(22)2 are	(32)2 regulator
(3)27 and	(13)3 at	(23)2 bias,	(33)2 relationship
(4)21 of	(14)3 bias	(24)2 burden	(34)2 surface
(5)20 in	(15)3 genes	(25)2 compared	(35)2 theory
(6)11 was	(16)3 the	(26)2 curve	(36)2 time
(7)8 that	(17)3 through	(27)2 during	(37)2 when
(8)7 is	(18)3 were	(28)2 from
(9)5 by	(19)2 (UPR)	(29)2 observed
(10)5 rate	(20)2 across	(30)2 our

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---