ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for response out of >500 occurrences
343831 occurrences (No.54 in the rank) during 5 years in the PubMed. [no cache] 500 found
8) Accordingly, when we knock down Survivin in human ccRCC cells we are able to restore caspase activity in response to DNA damage.
--- ABSTRACT ---
PMID:24469044 DOI:10.1038/onc.2013.598
2015 Oncogene
* The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2.
- Functional loss of the von Hippel-Lindau (VHL) tumor suppressor protein (pVHL), which is part of an E3-ubiquitin ligase complex, initiates most inherited and sporadic clear-cell renal cell carcinomas (ccRCC). Genetic inactivation of the TP53 gene in ccRCC is rare, suggesting that an alternate mechanism alleviates the selective pressure for TP53 mutations in ccRCC. Here we use a zebrafish model to describe the functional consequences of pVHL loss on the p53/Mdm2 pathway. We show that p53 is stabilized in the absence of pVHL and becomes hyperstabilized upon DNA damage, which we propose is because of a novel in vivo interaction revealed between human pVHL and a negative regulator of Mdm2, the programmed cell death 5 (PDCD5) protein. PDCD5 is normally localized at the plasma membrane and in the cytoplasm. However, upon hypoxia or loss of pVHL, PDCD5 relocalizes to the nucleus, an event that is coupled to the degradation of Mdm2. Despite the subsequent hyperstabilization and normal transcriptional activity of p53, we find that zebrafish vhl(-/-) cells are still as highly resistant to DNA damage-induced cell cycle arrest and apoptosis as human ccRCC cells. We suggest this is because of a marked increase in expression of birc5a, the zebrafish homolog of Survivin. Accordingly, when we knock down Survivin in human ccRCC cells we are able to restore caspase activity in response to DNA damage. Taken together, our study describes a new mechanism for p53 stabilization through PDCD5 upon hypoxia or pVHL loss, and reveals new clinical potential for the treatment of pathobiological disorders linked to hypoxic stress.
--- ABSTRACT END ---
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[frequency of next (right) word to response]
(1)146 to (14)4 proteins (27)3 time (40)2 following
(2)32 *null* (15)4 rates (28)3 times (41)2 from
(3)31 and (16)4 that (29)3 which (42)2 including
(4)22 of (17)4 the (30)2 (ABR) (43)2 latency
(5)21 rate (18)3 at (31)2 (DDR) (44)2 mediated
(6)14 was (19)3 during (32)2 (UPR) (45)2 or
(7)13 in (20)3 elements (33)2 after (46)2 rate)
(8)8 selection (21)3 models (34)2 are (47)2 rates,
(9)7 surface (22)3 options (35)2 boundaries (48)2 such
(10)6 data (23)3 properties (36)2 delays (49)2 theory
(11)6 is (24)3 strategies (37)2 effects (50)2 validity
(12)4 for (25)3 style (38)2 element (51)2 were
(13)4 patterns (26)3 suppression (39)2 evaluation

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--- WordNet output for response --- =>反応, 応答, 返答, 返報, 反響, 答唱句 Overview of noun response The noun response has 7 senses (first 5 from tagged texts) 1. (11) response -- (a result; "this situation developed in response to events in Africa") 2. (11) reaction, response -- (a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age") 3. (6) answer, reply, response -- (a statement (either spoken or written) that is made to reply to a question or request or criticism or accusation; "I waited several days for his answer"; "he wrote replies to several of his critics") 4. (4) reception, response -- (the manner in which something is greeted; "she did not expect the cold reception she received from her superiors") 5. (1) response -- (a phrase recited or sung by the congregation following a versicle by the priest or minister) 6. reply, response -- (the speech act of continuing a conversational exchange; "he growled his reply") 7. response -- (the manner in which an electrical or mechanical device responds to an input signal or a range of input signals) --- WordNet end ---