kwic
show
show
right
off
ON
19
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for show out of >500 occurrences
663834 occurrences (No.9 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to show]
663834 occurrences (No.9 in the rank) during 5 years in the PubMed. [cache]
| 19) We show that ELOF1 has an evolutionarily conserved role in transcription-coupled nucleotide excision repair (TC-NER), where it promotes recruitment of the TC-NER factors UVSSA and TFIIH to efficiently repair transcription-blocking lesions and resume transcription. |
| PMID:34108662 DOI:10.1038/s41556-021-00692-z |
| 2021 Nature cell biology |
| * Elongation factor ELOF1 drives transcription-coupled repair and prevents genome instability. |
| - Correct transcription is crucial for life. However, DNA damage severely impedes elongating RNA polymerase II, causing transcription inhibition and transcription-replication conflicts. Cells are equipped with intricate mechanisms to counteract the severe consequence of these transcription-blocking lesions. However, the exact mechanism and factors involved remain largely unknown. Here, using a genome-wide CRISPR-Cas9 screen, we identified the elongation factor ELOF1 as an important factor in the transcription stress response following DNA damage. We show that ELOF1 has an evolutionarily conserved role in transcription-coupled nucleotide excision repair (TC-NER), where it promotes recruitment of the TC-NER factors UVSSA and TFIIH to efficiently repair transcription-blocking lesions and resume transcription. Additionally, ELOF1 modulates transcription to protect cells against transcription-mediated replication stress, thereby preserving genome stability. Thus, ELOF1 protects the transcription machinery from DNA damage via two distinct mechanisms. |
[
right
kwic]
(1)316  that |
(7)4 in |
(13)2 different |
(19)2 limited |
| (2)28 a |
(8)3 any |
(14)2 evidence |
(20)2 significant |
| (3)19 the |
(9)3 increased |
(15)2 extensive |
(21)2 that, |
| (4)10 how |
(10)3 strong |
(16)2 for |
(22)2 that: |
| (5)9 promise |
(11)2 both |
(17)2 here |
(23)2 these |
| (6)6 an |
(12)2 by |
(18)2 highly |
add keyword
--- WordNet output for show ---