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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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663834 occurrences (No.9 in the rank) during 5 years in the PubMed. [cache]
163) Our results showed that the fluorescent signal from our antibody-based probe could differentiate whole lungs of macaques infected for 9 days from those infected for 2 or 3 days.
* Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques.
- Infection with the novel coronavirus, SARS-CoV-2, results in pneumonia and other respiratory symptoms as well as pathologies at diverse anatomical sites. An outstanding question is whether these diverse pathologies are due to replication of the virus in these anatomical compartments and how and when the virus reaches those sites. To answer these outstanding questions and study the spatiotemporal dynamics of SARS-CoV-2 infection a method for tracking viral spread in vivo is needed. We developed a novel, fluorescently labeled, antibody-based in vivo probe system using the anti-spike monoclonal antibody CR3022 and demonstrated that it could successfully identify sites of SARS-CoV-2 infection in a rhesus macaque model of COVID-19. Our results showed that the fluorescent signal from our antibody-based probe could differentiate whole lungs of macaques infected for 9 days from those infected for 2 or 3 days. Additionally, the probe signal corroborated the frequency and density of infected cells in individual tissue blocks from infected macaques. These results provide proof of concept for the use of in vivo antibody-based probes to study SARS-CoV-2 infection dynamics in rhesus macaques.
Overview of verb show
The verb show has 12 senses (first 11 from tagged texts)
1. (136) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested
audience; "She shows her dogs frequently"; "We will demo the new software in Washington")
2. (63) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an
example, explanation or experiment; "The experiment demonstrated the instability of the compound";
"The mathematician showed the validity of the conjecture")
3. (57) testify, bear witness, prove, evidence, show -- (provide evidence for; "The blood test
showed that he was the father"; "Her behavior testified to her incompetence")
4. (43) show -- (make visible or noticeable; "She showed her talent for cooking"; "Show me your
etchings, please")
5. (32) picture, depict, render, show -- (show in, or as in, a picture; "This scene depicts country
life"; "the face of the child is rendered with much tenderness in this painting")
6. (24) express, show, evince -- (give expression to; "She showed her disappointment")
7. (24) indicate, point, designate, show -- (indicate a place, direction, person, or thing; either
spatially or figuratively; "I showed the customer the glove section"; "He pointed to the empty
parking space"; "he indicated his opponents")
8. (11) show, show up -- (be or become visible or noticeable; "His good upbringing really shows";
"The dirty side will show")
9. (7) read, register, show, record -- (indicate a certain reading; of gauges and instruments; "The
thermometer showed thirteen degrees below zero"; "The gauge read `empty'")
10. (6) show -- (give evidence of, as of records; "The diary shows his distress that evening")
11. (2) usher, show -- (take (someone) to their seats, as in theaters or auditoriums; "The usher
showed us to our seats")
12. show -- (finish third or better in a horse or dog race; "he bet $2 on number six to show")
--- WordNet end ---