ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]
101) Our analysis shows that taking the delayed diagnosis into account gives a mildly different estimate of progression rate to cirrhosis and significantly lower estimated progression rate to HCV-related death in comparison with conventional modelling.
* Impact of delayed diagnosis time in estimating progression rates to hepatitis C virus-related cirrhosis and death.
- Delay of the diagnosis of hepatitis C virus (HCV), and its treatment to avert cirrhosis, is often present sincethe early stage of HCV progression is latent. Current methods to determine the incubation time to HCV-related cirrhosis and the duration time from cirrhosis to subsequent events (e.g. complications or death) used to be based on the time of liver biopsy diagnosis and ignore this delay which led to an interval censoring for the first event time and a double censoring for the subsequent event time. To investigate the impact of this delay in estimating HCV progression rates and relevant estimating bias, we present a correlated two-stage progression model for delayed diagnosis time and fit the developed model to the previously studied hepatitis C cohort data from Edinburgh. Our analysis shows that taking the delayed diagnosis into account gives a mildly different estimate of progression rate to cirrhosis and significantly lower estimated progression rate to HCV-related death in comparison with conventional modelling. We also find that when the delay increases, the bias in estimating progression increases significantly.
=>きわめて, 意味深く, 意味ありげに
Overview of adv significantly
The adv significantly has 3 senses (first 2 from tagged texts)
1. (6) significantly -- (in a statistically significant way; "the two groups differed
significantly")
2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by
these new cuts")
3. importantly, significantly -- (in an important way or to an important degree; "more importantly,
Weber held that the manifold meaning attached to the event by the social scientist could alter his
definition of the concrete event itself")
--- WordNet end ---