ELIZA

return kwic search for significantly out of >500 occurrences
583352 occurrences (No.14 in the rank) during 5 years in the PubMed. [cache]

199) Direct saliva 90.5%, (95% CI: 82%, 95%), followed by NP swabs in VTM and saliva in eNAT, was significantly more sensitive than nasal swabs in VTM (50%, P<0.001) or eNAT (67.8%, P=0.0012) and oral swabs in VTM (50%, P<0.0001) or eNAT (56%, P<0.0001).

--- ABSTRACT ---

PMID:33688680 DOI:10.1101/2021.03.03.21251172

2021 medRxiv : the preprint server for health sciences

* Evaluation of sample collection and transport strategies to enhance yield, accessibility, and biosafety of COVID-19 RT-PCR testing.

- Sensitive, accessible, and biosafe sampling methods for COVID-19 reverse-transcriptase polymerase chain reaction (RT-PCR) assays are needed for frequent and widespread testing. We systematically evaluated diagnostic yield across different sample collection and transport workflows, including the incorporation of a viral inactivation buffer. We prospectively collected nasal swabs, oral swabs, and saliva, from 52 COVID-19 RT-PCR-confirmed patients, and nasopharyngeal (NP) swabs from 37 patients. Nasal and oral swabs were placed in both viral transport media (VTM) and eNAT™, a sterilizing transport buffer, prior to testing with the Xpert Xpress SARS-CoV-2 (Xpert) test. The sensitivity of each sampling strategy was compared using a composite positive standard. Overall, swab specimens collected in eNAT showed superior sensitivity compared to swabs in VTM (70% vs 57%, P=0.0022). Direct saliva 90.5%, (95% CI: 82%, 95%), followed by NP swabs in VTM and saliva in eNAT, was significantly more sensitive than nasal swabs in VTM (50%, P<0.001) or eNAT (67.8%, P=0.0012) and oral swabs in VTM (50%, P<0.0001) or eNAT (56%, P<0.0001). Saliva and use of eNAT buffer each increased detection of SARS-CoV-2 with the Xpert test; however, no single sample matrix identified all positive cases.

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[frequency of next (right) word to significantly]

(1)44 higher	(17)6 with	(33)4 in	(49)2 faster
(2)35 increased	(18)5 and	(34)4 suppressed	(50)2 increases
(3)33 associated	(19)5 better	(35)3 (p	(51)2 influence
(4)25 reduced	(20)5 enhanced	(36)3 change	(52)2 inhibit
(5)20 lower	(21)5 enriched	(37)3 diminished	(53)2 larger
(6)19 decreased	(22)5 less	(38)3 increase	(54)2 lowered
(7)15 different	(23)5 related	(39)3 longer	(55)2 modified
(8)14 more	(24)4 null	(40)2 (P	(56)2 over
(9)13 greater	(25)4 altered	(41)2 affected	(57)2 positively
(10)12 improved	(26)4 between	(42)2 alleviated	(58)2 prolong
(11)11 correlated	(27)4 by	(43)2 alter	(59)2 reduce
(12)10 inhibited	(28)4 downregulated	(44)2 at	(60)2 reduces
(13)6 attenuated	(29)4 elevated	(45)2 changed	(61)2 reversed
(14)6 predicted	(30)4 impact	(46)2 declined
(15)6 to	(31)4 improve	(47)2 decreased,
(16)6 upregulated	(32)4 improves	(48)2 expanded

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--- WordNet output for significantly --- =>きわめて, 意味深く, 意味ありげに Overview of adv significantly The adv significantly has 3 senses (first 2 from tagged texts) 1. (6) significantly -- (in a statistically significant way; "the two groups differed significantly") 2. (3) significantly -- (in a significant manner; "our budget will be significantly affected by these new cuts") 3. importantly, significantly -- (in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself") --- WordNet end ---