211) The tumor suppressor p53, nuclear factor-κB (NF-κB) and reactive oxygen species (ROS) have crucial roles in tumorigenesis, although the mechanisms of cross talk between these factors remain largely unknown. |
PMID:24469051 DOI:10.1038/onc.2013.597 |
2015 Oncogene |
* Selective killing of lung cancer cells by miRNA-506 molecule through inhibiting NF-κB p65 to evoke reactive oxygen species generation and p53 activation. |
- The tumor suppressor p53, nuclear factor-κB (NF-κB) and reactive oxygen species (ROS) have crucial roles in tumorigenesis, although the mechanisms of cross talk between these factors remain largely unknown. Here we report that miR-506 upregulation occurs in 83% of lung cancer patients (156 cases), and its expression highly correlates with ROS. Ectopic expression of miR-506 inhibits NF-κB p65 expression, induces ROS accumulation and then activates p53 to suppress lung cancer cell viability, but not in normal cells. Interestingly, p53 promotes miR-506 expression level, indicating that miR-506 mediates cross talk between p53, NF-κB p65 and ROS. Furthermore, we demonstrated that miR-506 mimics inhibited tumorigenesis in vivo, implicating that miR-506 might be a potential therapeutic molecule for selective killing of lung cancer cells. |
(1)93 *null* | (11)7 but | (21)3 can | (31)2 for |
(2)46 of | (12)7 with | (22)3 could | (32)2 found |
(3)34 in | (13)6 identification | (23)3 differences | (33)2 generated |
(4)31 and | (14)5 determination | (24)3 have | (34)2 identification, |
(5)19 (ROS) | (15)5 that | (25)3 level | (35)2 including |
(6)18 were | (16)4 as | (26)3 may | (36)2 phytotoxicity |
(7)12 is | (17)4 or | (27)2 (ROS), | (37)2 rather |
(8)10 are | (18)4 to | (28)2 (overall | (38)2 such |
(9)9 from | (19)4 which | (29)2 M | |
(10)9 was | (20)3 AEJ-89 | (30)2 along |
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