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321753 occurrences (No.65 in the rank) during 5 years in the PubMed. [no cache] 500 found
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321753 occurrences (No.65 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 319) The generation of reactive oxygen species, or ROS, is an inevitable aspect of existence under aerobic conditions. |
| PMID:24041414 DOI:10.3109/1040841X.2013.829416 |
| 2015 Critical reviews in microbiology |
| * Coupling of transcriptional response to oxidative stress and secondary metabolism regulation in filamentous fungi. |
| - To survive sudden and potentially lethal changes in their environment, filamentous fungi must sense and respond to a vast array of stresses, including oxidative stresses. The generation of reactive oxygen species, or ROS, is an inevitable aspect of existence under aerobic conditions. In addition, in the case of fungi with pathogenic lifestyles, ROS are produced by the infected hosts and serve as defense weapons via direct toxicity, as well as effectors in fungal cell death mechanisms. Filamentous fungi have thus developed complex and sophisticated responses to evade oxidative killing. Several steps are determinant in these responses, including the activation of transcriptional regulators involved in the control of the antioxidant machinery. Gathering and integrating the most recent advances in knowledge of oxidative stress responses in fungi are the main objectives of this review. Most of the knowledge coming from two models, the yeast Saccharomyces cerevisiae and fungi of the genus Aspergillus, is summarized. Nonetheless, recent information on various other fungi is delivered when available. Finally, special attention is given on the potential link between the functional interaction between oxidative stress and secondary metabolism that has been suggested in recent reports, including the production of mycotoxins. |
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