ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for species out of >500 occurrences
321753 occurrences (No.65 in the rank) during 5 years in the PubMed. [cache]
97) Sensitivity to potential endocrine disrupting chemicals in the environment varies across species and is influenced by sequence conservation of their nuclear receptor targets.
--- ABSTRACT ---
PMID:33049310 DOI:10.1016/j.tiv.2020.105016
2021 Toxicology in vitro : an international journal published in association with BIBRA
* Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment.
- Sensitivity to potential endocrine disrupting chemicals in the environment varies across species and is influenced by sequence conservation of their nuclear receptor targets. Here, we evaluated a multiplexed, in vitro assay testing receptors relevant to endocrine and metabolic disruption from five species. The TRANS-FACTORIAL™ system of human nuclear receptors was modified to include additional species: mouse (Mus musculus), frog (Xenopus laevis), zebrafish (Danio rerio), chicken (Gallus gallus), and turtle (Chrysemys picta). Receptors regulating endocrine function and xenobiotic recognition were included, specifically: ERα, ERβ, AR, TRα, TRβ, PPARγ and PXR. The assay, ECOTOX-FACTORIAL™, was evaluated with 191 chemicals enriched with known receptor ligands. Hierarchical clustering of potency values demonstrated strong coherence of receptor families. Interspecies comparisons of responses within a receptor family showed moderate to high concordance for potencies under 50 μM. PPARγ showed high concordance between mammalian species, 89%, but only 63% between mammalian and zebrafish. For chemicals with potencies below 1 μM, concordances were 89-100% for all receptors except PXR. Concordance showed a strong positive relationship to ligand-binding domain sequence similarity and critical amino acid residues obtained by the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) tool. In combination with SeqAPASS, ECOTOX-FACTORIAL may provide efficient screening of important receptors to identify species of high priority for effects monitoring.
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(1)68 *null* (11)8 including (21)3 (e.g., (31)3 within
(2)62 and (12)6 from (22)3 D (32)2 approach
(3)26 of (13)6 was (23)3 also (33)2 be
(4)24 (ROS) (14)5 has (24)3 by (34)2 but
(5)20 in (15)5 to (25)3 can (35)2 distribution
(6)13 that (16)5 we (26)3 may (36)2 have
(7)11 with (17)4 (ROS), (27)3 or (37)2 identification
(8)10 differences (18)4 as (28)3 production (38)2 level
(9)9 were (19)4 difference (29)3 the (39)2 such
(10)8 are (20)4 is (30)3 which

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--- WordNet output for species --- =>人類, 種, 種類 Overview of noun species The noun species has 2 senses (first 2 from tagged texts) 1. (27) species -- ((biology) taxonomic group whose members can interbreed) 2. (5) species -- (a specific kind of something; "a species of molecule"; "a species of villainy") Overview of noun specie The noun specie has 1 sense (no senses from tagged texts) 1. coinage, mintage, specie, metal money -- (coins collectively) --- WordNet end ---