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279736 occurrences (No.90 in the rank) during 5 years in the PubMed. [cache]

141) Similarly, available evidence indicates that many metabolites of N3FA are synthesized by mammalian cells and that they exert metabolite-specific biological activities.

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PMID:35008321 DOI:10.3390/cancers14010157

2021 Cancers

* Building a Foundation for Precision Onco-Nutrition: Docosahexaenoic Acid and Breast Cancer.

- In vivo evidence of heterogeneous effects of n-3 fatty acids (N3FA) on cell signaling pathways associated with the reduced growth of breast cancer has been reported and is consistent with the expectation that N3FA will not exert uniform effects on all molecular subtypes of the disease. Similarly, available evidence indicates that many metabolites of N3FA are synthesized by mammalian cells and that they exert metabolite-specific biological activities. To begin to unravel the complex relationships among molecular subtypes and effects exerted by specific N3FA metabolites on those pathways, proof-of-concept experiments were conducted using cell lines representative of common molecular subtypes of human breast cancer. N3FA differed in anticancer activity with docosahexaenoic acid (DHA) having greater anticancer activity than eicosapentaenoic acid. 4-oxo-docosahexaenoic (4-oxo-DHA), a penultimate metabolite of 5-lipoxygenase mediated DHA metabolism, induced dose-dependent inhibition of cell number accumulation with apoptosis as a primary effector mechanism. Interrogation of protein expression data using the Ingenuity Pathway Analysis (IPA) bioinformatics platform indicated that 4-oxo-DHA differentially impacted six canonical pathways and the cellular functions they regulate across common molecular subtypes of breast cancer. This included the endocannabinoid pathway for cancer inhibition that has not been previously reported. These findings provide a rationale for juxtaposing molecular subtype targeted treatment strategies with the adjuvant use of specific N3FA metabolites as an example of precision onco-nutrition (PON) for the management and control of breast cancer.

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(1)18 to	(21)3 for	(41)2 food	(61)2 or
(2)11 and	(22)3 genes	(42)2 foods	(62)2 parameters
(3)8 focus	(23)3 genetic	(43)2 gene	(63)2 patient
(4)7 vulnerability	(24)3 marker	(44)2 granule	(64)2 physical
(5)6 effects	(25)3 mechanisms	(45)2 group	(65)2 proteases
(6)6 factors	(26)3 proteins	(46)2 groups	(66)2 research
(7)5 recommendations	(27)2 GC	(47)2 immune	(67)2 responses
(8)4 IgA	(28)2 N3FA	(48)2 in	(68)2 risk
(9)4 aspects	(29)2 PHC	(49)2 information	(69)2 sensitization
(10)4 cancer	(30)2 antibodies	(50)2 interventional	(70)2 siRNA
(11)4 components	(31)2 antigens	(51)2 interventions	(71)2 social
(12)4 inhibitor	(32)2 area	(52)2 issues	(72)2 spatial
(13)4 population	(33)2 attention	(53)2 knockout	(73)2 study
(14)3 T	(34)2 binding	(54)2 mental	(74)2 target
(15)3 brain	(35)2 biological	(55)2 microbial	(75)2 terms
(16)3 cell	(36)2 biomarkers	(56)2 molecular	(76)2 topics
(17)3 changes	(37)2 cellular	(57)2 mortality	(77)2 treatment
(18)3 counseling	(38)2 clinical	(58)2 mutations	(78)2 type
(19)3 deletion	(39)2 emphasis	(59)2 needs
(20)3 differences	(40)2 factors,	(60)2 online

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--- WordNet output for specific --- =>特有の, 特効薬, 明確な, 特定の, 種の, はっきりした Overview of noun specific The noun specific has 2 senses (no senses from tagged texts) 1. particular, specific -- (a fact about some part (as opposed to general); "he always reasons from the particular to the general") 2. specific -- (a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria") Overview of adj specific The adj specific has 4 senses (first 2 from tagged texts) 1. (39) specific -- ((sometimes followed by `to') applying to or characterized by or distinguishing something particular or special or unique; "rules with specific application"; "demands specific to the job"; "a specific and detailed account of the accident") 2. (5) specific -- (stated explicitly or in detail; "needed a specific amount") 3. specific -- (relating to or distinguishing or constituting a taxonomic species; "specific characters") 4. specific -- (being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements") --- WordNet end ---